A CASE OF ABSCESSED PNEUMONIA DUE TO COVID-19 INFECTION IN A YOUNG PATIENT


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Abstract

Viral infections are the first ranked conditions among infectious diseases causing 5-15% of all community-acquired pneumonia. The aim of the study was to describe a case of COVID-19 infection, proceeding with acquired bacterial infection and developing abscess pneumonia in a young patient. Material and methods. The accompanying medical documentation was examined, clinical and morphological analysis was carried out for assessing macro- and micropreparations. Patient A.E., 31 years old, within 5 hours 10 minutes was at in-hospital treatment with a diagnosis of Coronavirus infection, severe course. Community-acquired bilateral polysegmental pneumonia. The patient admitted with complaints of respiratory difficulty, shortness of breath, weakness, fever up to febrile level, severe pain in the right groin area, both lower extremities, swelling in hands and feet. However, despite initiated treatment, the patient's condition worsened and biological death was verified. The postmortem examination revealed signs of total bilateral hemorrhagic pneumonia. Histological examination showed areas of necrosis in the alveolar epithelium and signs of marked edema with a hemorrhagic component; hemolyzed erythrocytes were found in alveolar lumen. Focal hemorrhages were visualized in the pulmonary parenchyma, sometimes merging along with lung tissue with forming microabscesses. a well-defined shaft consisting of granular leukocytes and congested vessels with erythrocyte sludge was noted on the periphery of necrosis area. In the alveoli located closer to the abscesses, fibrinous and serous exudate was detected. Signs of edema were observed in the brain; histological examination revealed perivascular, pericellular optical voids with vascular congestion, erythrocyte sludge and minor hemorrhages. SARS-CoV-2-caused pneumonia and acquired bacterial infection, in this case due to staphylococcus, led to abscess pneumonia and severe respiratory failure with developing acute distress syndrome. Obviously, the high frequency of destructive processes in staphylococcal pneumonia is due to the pathogenic staphylococci characterized by production of high-level proteolytic enzymes destroying body tissues. Thus, the current case of COVID-19 infection in a young patient is of particular importance and relevance, because it demonstrates an unfavorable disease outcome despite patient young age and lack of concomitant pathology.

About the authors

О. V. Vorobeva

Federal State Educational Institution of Higher Education “Chuvash State University after I.N. Ulyanova

Email: olavorobeva@mail.ru
ORCID iD: 0000-0003-3259-3691

Associate Professor of the Department of General and Clinical Morphology and Forensic Medicine

Russian Federation

L. P. Romanova

Federal State Educational Institution of Higher Education “Chuvash State University after I.N. Ulyanova

Author for correspondence.
Email: samung2008@yandex.ru
ORCID iD: 0000-0003-0556-8490

Associate Professor of the Department of Dermatovenereology 
with a Hygiene Course
 
Russian Federation

References

  1. Воробьева О.В. Изменения в органах при инфицировании COVID-19 с развитием септикопиемии. Профилактическая медицина. 2021. Т. 24. № 10. С. 89-93.
  2. Воробьева О.В., Ласточкин А.В. Патоморфологические изменения в органах при COVID-19 // Инфекция и иммунитет. 2020. Т. 10, №3. С. 587-590. https://doi.org/10.15789/2220-7619-PCI-1483
  3. Alsaad KO, Hajeer AH, Al Balwi M et al. Histopathology of Middle East respiratory syndrome coronavirus (MERS-CoV) infection - clinicopathological and ultrastructural study. Histopathology. 2018, vol.72, pp. 516-524
  4. Hwang DM, Chamberlain DW, Poutanen SM et al. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol. 2005, vol.18, pp.1-10
  5. Liu J, Zheng X, Tong Q et al. Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV. J Med Virol. 2020, vol. 92, pp. 491-494
  6. Zhang H, Zhou P, Hu M et al. Histopathologic changes and SARS-CoV-2 immunostaining in the lung of a patient with COVID-19. Ann Inter Med. 2020, vol. 172, pp. 629-632
  7. Zhou P., Yang X.L., Wang X.G. et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020. vol. 579, no. 7798., pp. 270-273. doi: 10.1038/s41586-020-2012-7.

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Copyright (c) vorobeva o.v., Petrovna R.L.

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