DETECTION OF CLASS IgG ANTIBODIES SPECIFIC TO SOME FLAVIVIRUSES IN THE POPULATION OF THE REPUBLIC OF GUINEA



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Abstract

Abstract.

Introduction. Genus Flavivirus (family Flaviviridae) viruses profoundly contribute to the spread of arbovirus infections. In the territory of the Republic of Guinea, the circulation of flaviviruses such as yellow fever virus (YFV), West Nile virus (WNV) and dengue fever virus (DENV) has been confirmed.

The aim of the study was to determine the level of IgG antibodies specific to YFV, DENV and WNV in the indigenous population in various landscape and geographical zones of the Republic of Guinea.

Materials and methods. For the study, a panel of 1559 human blood sera were compiled, which were collected in all landscape and geographical zones. The detection of IgG antibodies against DENV and WNV was carried out by commercial test systems, YFV – by an experimental ELISA test system based on an analog of the third domain of protein E.

Results. While testing 1559 blood serum samples, 28.48% (95% CI: 26.3-30.7) of cases were found to have IgG antibodies against YFV, DENV – in 11,8%, (95% CI: 10,3-13,5) and WNV – in 27% (95% CI: 24,8-29,3). simultaneously, antibodies against the three viruses (YFV, DENV and WNV) were detected in 30 cases, YFV and DENV – in 14, YFV and WNV – in 44, DENV and WNV – in 56 cases.

Conclusions. The detection of antibodies to WNV and DENV confirms the continued circulation of these pathogens in the territory of the Republic of Guinea, which poses a risk to the health of the indigenous population. The level of IgG class antibodies against YFV is insufficient for formation of yellow fever herd immunity, because. according to the WHO, it should reach at least 80% of the total indigenous population.

About the authors

Ekaterina I. Krivosheina

State Scientific Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation

Email: katr962@mail.ru
ORCID iD: 0000-0001-5181-0415

Researcher at the Department of Development and Production of Diagnostic Tools for Viral Diseases

Russian Federation, Kol’tsovo, Russia

Michael Yu. Kartashov

State Scientific Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation

Email: mikkartash@yandex.ru
ORCID iD: 0000-0002-7857-6822

PhD, MD (Biology), Senior Researcher, Department of Flavivirus Infections

Russian Federation, Kol’tsovo, Russia

Nikita D. Ushkalenko

State Scientific Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation

Email: ushkalenko_nd@vector.nsc.ru
ORCID iD: 0000-0002-2171-7444

Junior Researcher, Department of development and production of diagnostic tools for viral diseases

Koltsovo, Russian Federation

Kirill A. Svirin

State Scientific Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation

Email: svirin_ka@vector.nsc.ru

Junior Researcher Department of Development and Production of Diagnostic Tools for Viral Diseases

Kol’tsovo, Russia

Ibrahim Nourdine

Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea

Email: fake@neicon.ru

Сотрудник Исследовательского института прикладной биологии Гвинеи

Kindia, Republic of Guinea

Sanaba Boumbaly

Research Institute of Applied Biology of Guinea, Kindia, Republic of Guinea

Email: fake@neicon.ru

Researcher at the Research Institute of Applied Biology of Guinea

Kindia, Republic of Guinea

Vladimir A. Ternovoy

State Scientific Center of Virology and Biotechnology «Vector», Koltsovo, Novosibirsk region, Russian Federation

Author for correspondence.
Email: tern@vector.nsc.ru
ORCID iD: 0000-0003-1275-171X

Head of the Department of Flavivirus Infections

Koltsovo,Russia

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Copyright (c) Krivosheina E., Kartashov M., Naidenova E., Ushkalenko N., Svirin K., Nourdine I., Boumbaly S., Ternovoy V.

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