New data on the level of immune stratum against Q fever agent in population of the of Republic of Guinea

Cover Page


Cite item

Full Text

Abstract

which is bacteria of the species Coxiella burnetii. One of the factors showing the possibility of pathogen circulation in a certain territory is assessed by the presence of an immune stratum in the inhabitants of the region. In the 1980s, the study of the immune structure of the population of the Republic of Guinea in relation to coxiellosis has begun. The present study, carried out in 2015—2019, has been aimed to obtain new information about the immune stratum of the population of the Republic of Guinea against the causative agent of Q fever and to compare it with previous studies. Specific IgG antibodies in the blood of the Guinea residents were detected by using enzyme-linked immunosorbent assay (ELISA) with a set of reagents manufactured at the St. Petersburg Pasteur Institute (St. Petersburg, Russian Federation). The serum samples were tested in at 1:100 dilution. Antibodies against C. burnetii were detected in 124/2346 (5.3% [CI 4.5-6.3]) samples. This study confirms the previously obtained data on the circulation of the causative agent of coxiellosis in all landscape and geographical zones of the Republic of Guinea. The natural and climatic conditions of the region, the variety of ixodic tick species currently inhabiting this territory being a reservoir and vector of infection, as well as a large amount of livestock are the factors for active circulation of the Q fever pathogen and the emergence of related disease outbreaks. The data obtained necessitate continuing further studies on distribution of C. burnetii in the territory of the Republic of Guinea. Taking into consideration the epidemiological significance of Q fever, a pressing task is to study a proportion of this infectious disease in the overall structure of diseases registered in the territory of the Republic of Guinea. It is also necessary to conduct regular epizootological monitoring in order to clarify the types of carriers and vectors of C. burnetii in different landscape and geographical zones of the Republic of Guinea as well as to assess the immune stratum against the pathogen in large and small cattle being the main sources of infection for humans. The data obtained will allow us to determine presence of a natural focus of this infection as well as its borders and develop a set of preventive (anti-epidemic) measures.

About the authors

E. V. Naydenova

Russian Research Anti-Plague Institute «Microbe» of Rospotrebnadzor

Author for correspondence.
Email: katim2003@mail.ru
ORCID iD: 0000-0001-6474-3696

Ekaterina V. Naidenova - PhD, MD (Biology), Senior Researcher, Laboratory of Virology, Department of Infectious Diseases Diagnostics.

410005, Saratov, Universitetskaya str., 46, Phone: +7 (996) 203-37-97

Россия

S. Kalivogui

Research Institute of Applied Biology

Email: sibakalvoui@yahoo.fr

PhD, MD (Biology), Senior Research Associate.

Kindia, Republic of Guinea Гвинея

M. Yu. Kartashov

State Scientific Center of Virology and Biotechnology Vector of Rospotrebnadzor

Email: kartashov_myu@vector.nsc.ru

PhD, MD (Biology), Senior Researcher, Department of Flavivirus Infections.

Koltsovo, Novosibirsk Region Россия

A. V. Boyko

Russian Research Anti-Plague Institute «Microbe» of Rospotrebnadzor

Email: boyko49@yandex.ru

PhD, MD (Medicine), Leading Researcher, Laboratory of Operative Diagnostics of the Department of Diagnostics of Infectious Diseases.

Saratov

Россия

S. Boumbaly

Research Institute of Applied Biology

Email: drboumbaly@yahoo.fr

PhD, MD (Biology), Deputy Director of the Research Institute of Applied Biology.

Kindia, Republic of Guinea

Гвинея

V. A. Safronov

Russian Research Anti-Plague Institute «Microbe» of Rospotrebnadzor

Email: neuromail@rambler.ru

PhD, MD (Medicine), Senior Researcher, Department of Epidemiology.

Saratov

Россия

K. S. Zakharov

Russian Research Anti-Plague Institute «Microbe» of Rospotrebnadzor

Email: zaharov_ks@mail.ru
ORCID iD: 0000-0002-4726-309X

PhD, MD (Biology), Researcher, Department of Epidemiology

Saratov

Россия

A. A. Nassour

Research Institute of Applied Biology

Email: ahmatnassourabdoulaye@gmail.com

Research Assistant.

Kindia, Republic of Guinea Гвинея

F. Drame

Research Institute of Applied Biology

Email: ahmatnassourabdoulaye@gmail.com

Research Assistant.

Kindia, Republic of Guinea

Гвинея

O. K. Konstantinov

Research Institute of Applied Biology

Email: olegkonst@mail.ru

PhD, MD (Biology), Researcher.

Kindia, Republic of Guinea Гвинея

N. F. Magassouba

Gamal Abdel Naser University

Email: cmagassouba01@gmail.com

PhD, MD (Medicine), Associate Professor, Department of Medical Microbiology.

Conakry, Republic of Guinea

Гвинея

M. A. Boiro

Research Institute of Applied Biology

Email: olegkonst@mail.ru

Boiro M., PhD, MD (Biology), Director.

Kindia, Republic of Guinea

Гвинея

S. А. Scherbakova

Russian Research Anti-Plague Institute «Microbe» of Rospotrebnadzor

Email: rusrapi@microbe.ru

PhD, MD (Biology), Deputy Director.

Saratov

Россия

V. Kutyrev

Russian Research Anti-Plague Institute «Microbe» of Rospotrebnadzor

Email: rusrapi@microbe.ru

RAS Full Member, PhD, MD (Medicine), Professor, Director.

Saratov

Россия

References

  1. Каливоги С., Буаро М.Е., Константинов О.К., Плотникова Л.Ф. Иммунная структура населения и домашних животных Гвинейской Республики в отношении риккетсиозов группы клещевой пятнистой лихорадки и лихорадки Ку // Медицинская паразитология и паразитарные болезни. 2013. № 1. С. 28—30.
  2. Лопатин А.А., Найденова Е.В., Сафронов В.А., Раздорский А.С., Уткин Д.В., Касьян Ж.А., Крицкий А.А., Терновой В.А., Нестеров А.Е., Сергеев А.А., Sylla A.L., Kanomou V., Boiro M.Y., Демина Ю.В., Хорошилов В.Ю., Попова А.Ю., Кутырев В.В. Изучение сохранения вируса Эбола в биологических жидкостях пациента на поздних стадиях выздоровления // Проблемы особо опасных инфекций. 2015. № 3. С. 73—77. doi: 10.21055/0370-1069-2015-3-73-76
  3. Найденова Е.В., Захаров К.С., Никифоров К.А., Карташов М.Ю., Агафонов Д.А., Касьян Ж.А., Плеханов Н.А., Поршаков А.М., Яковлев С.А., Пьянков С.А., Крицкий А.А., Оглодин Е.Г., Уткин Д.В., Баяндин Р.Б., Кабанов А.С., Сергеев Ал.А., Диалло М.Г., Нурдин И., Тупу Ж.-П., Диалло М., Кутырев И.В., Раздорский А.С., Сафронов В.А., Лопатин А.А., Бумбали С., Щербакова С.А., Буаро М.Й., Кутырев В.В. Итоги и перспективы изучения некоторых природно-очаговых инфекционных болезней в Гвинейской Республике. В кн.: Актуальные инфекции в Гвинейской Республике: эпидемиология, диагностика и иммунитет / Под ред. А.Ю. Поповой. СПб.: ФБУН НИИЭМ имени Пастера, 2017. C. 150—156.
  4. Найденова Е.В., Лопатин А.А., Сафронов В.А., Коломоец Е.В., Левковский А.Е., Силла А.Л., Старшинов В.А., Щербакова С.А., Малеев В.В. Обеспечение биологической безопасности при проведении противоэпидемических мероприятий в период ликвидации эпидемии лихорадки Эбола в Гвинейской Республике // Инфекционные болезни: новости, мнения, обучение. 2018. Т. 7, № 3. С. 102—108. doi: 10.24411/2305-3496-2018-13015
  5. Население Гвинеи // Countrymeters. URL: http://countrymeters.info/ru/guinea (25.10.2020)
  6. Панферова Ю.А. Молекулярные основы патогенности Coxiella burnetii // Инфекция и иммунитет. 2016. Т. 6, № 1. С. 7—24. doi: 10.15789/2220-7619-2016-1-7-24
  7. Специфическая индикация патогенных биологических агентов: практическое руководство / Под ред. Г.Г. Онищенко, В.В. Кутырева. 2-е изд., переработанное и дополненное. М.: ООО «Буква», 2014. 284 с.
  8. Черч Гаррисон Р.Дж. Западная Африка. Природная среда и ее хозяйственное использование. М.: Издательство иностранной литературы, 1959. 470 с.
  9. Mediannikov O., Fenollar F., Socolovschi C., Diatta G., Bassene H., Molez J.-F., Sokhna C., Trape J.-F., Raoul D. Coxiella burnetii in Humans and Ticks in Rural Senegal. PLoS Negl. Trop. Dis., vol. 4, no. 4: e654. doi: 10.1371/journal.pntd.0000654
  10. Noden B.H., Tshavuka F.I., van der Colf B.E., Chipare I., Wilkinson R. Exposure and risk factors to Coxiella burnetii, spotted fever group and typhus group rickettsiae and bartonella henselae among volunteer blood donors in Namibia. PLoS One, vol. 9, no. 9: e108674. doi: 10.1371/journal.pone.0108674
  11. Prabhu M., Nicholson W.L., Roche A.J., Kersh G.J., Fitzpatrick K.A., Oliver L.D., Massung R.F., Morrissey A.B., Bartlett J.A., Onyango J.J., Maro V.P., Kinabo G.D., Saganda W., Crump J.A. Q Fever, spotted fever group, and typhus group rickettsioses among hospitalized febrile patients in Northern Tanzania. Clin. Infect. Dis., 2011, vol. 53, no. 4: e8-15. doi: 10.1093/cid/cir411
  12. Vanderburg S., Rubach M.P., Halliday J., Cleaveland S., Reddy E.A., Crump J.A. Epidemiology of Coxiella burnetii infection in Africa: a one health systematic review. PLoS Negl. Trop. Dis., 2014, vol. 8, no. 4: e2787. doi: 10.1371/journal.pntd.0002787

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2021 Naydenova E.V., Kalivogui S., Kartashov M.Y., Boyko A.V., Boumbaly S., Safronov V.A., Zakharov K.S., Nassour A.A., Drame F., Konstantinov O.K., Magassouba N.F., Boiro M.A., Scherbakova S.А., Kutyrev V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies