Infiornativity lacrimal fluid interleukins in diagnostics and development of angle-closure glaucoma in elderly subjects

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Abstract

An increased percentage of the elderly subjects in pattern of contemporary society, along with other causes and risk factors, is accompanied by rise in the incidence of glaucoma. By 2020, according to international studies it is expected that prevalence of glaucoma patients in the world would increase up to 80 million subjects. Among the elderly, glaucoma is a common pathology, which development is associated with local disturbances in interleukin profile. However, the features of the latter in patients with primary closed-angle glaucoma in the elderly were poorly examined. Studies of local interleukin status were conducted mainly in patients with suspected or initial manifestations of primary open-angle glaucoma. The features of lacrimal fluid interleukin shift in a target group of elderly patients suffering from stage II primary closed-angle glaucoma virtually gained no attention. In addition, a limited range of local interleukins in patients with such pathology in previous studies was examined. In addition, informativity of lacrimal fluid interleukins in elderly glaucoma patients was not assessed too based on objective methods. The aim of the current study was to outline features and informativity of local interleukin profile indicators in 58 elderly patients with primary closed-angle glaucoma stage II, aged 60—74 years (main group) and 27 age-matched elderly subjects lacking such pathology. The level of interleukins in the lacrimal fluid was determined with the enzyme immunoassay “Multiscan” analyzer (Finland) by using sandwich ELISA (R&D Diagnostic Inc., USA). Informativity of measuring various interleukins was calculated according to the generally accepted formula. It was found that local interleukin profile in elderly patients with primary closed-angle glaucoma was mainly featured with increased amount of IL-2, IL-17, IL-8, but decreased IL-10. Hence, such local interleukins displayed peak informativity. The data obtained should be used in the diagnostics and treatment of such pathology, as well as of applied importance to unveil novel mechanisms behind development, diagnostics and corroboration for selective immuno-tropic therapy of primary closed-angle glaucoma.

About the authors

A. M. Chukhraiev

S. Fyodorov Eye Microsurgery Federal State Institution

Email: mntk@mntk.ya.ru

PhD, MD (Medicine), Professor, General Director.

Moscow

Russian Federation

N. M. Agarkov

South-West State University; Belgorod State National Research University

Author for correspondence.
Email: vitalaxen@mail.ru
ORCID iD: 0000-0002-8991-0910

Nikolai M. Agarkov - PhD, MD (Medicine), Professor, Professor of the Department of Biomedical Engineering.

305040, Kursk, 50 Let Oktyabrya str., 94, Phone: +7 910 740-96-13

Russian Federation

D. A. Konyaev

Fyodorov Eye Microsurgery Federal State Institution

Email: fake@neicon.ru

Ophthalmologist.

Tambov

Russian Federation

E. V. Popova

Fyodorov Eye Microsurgery Federal State Institution

Email: prashchaeu@yandex.ru

Popova E.V., Ophthalmologist.

Tambov Russian Federation

M. M. Yablokov

Fyodorov Eye Microsurgery Federal State Institution

Email: fake@neicon.ru

Ophthalmologist.

Tambov Russian Federation

A. S. Kulabukhov

Kursk State Medical University

Email: kurskmed@mail.ru

PhD (Medicine), Head of the Department of Nursing.

Kursk Russian Federation

References

  1. Авдеев Р.В., Александров А.С., Бакунина Н.А., Басинский А.С., Блюм Е.А., Брежнев А.Ю., Волков Е.Н., Газизова И.Р., Галимова А.Б., Гапонько О.В., Гарькавенко В.В., Гетманова А.М., Городничий В.В., Горшкова М.С., Гусаревич А.А., Диордийчук С.В., Дорофеев Д.А., Жаворонков С.А., Завадский П.Ч., Зверева О.Г., Каримов У.Р., Кулик А.В., Куроедов А.В., Ланин С.Н., Ловпаче Дж.Н., Лоскутов И.А., Молчанова В.В., Огородникова В.Ю., Онуфрийчук О.Н., Петров С.Ю., Рожко Ю.И., Сиденко Т.А. Прогнозирование продолжительности сроков заболевания и возраста пациентов с разными стадиями первичной открытоугольной глаукомы // Национальный журнал глаукомa. 2014. T. 13, № 2. С. 60—69.
  2. Азнабаев М.Т. Состояние офтальмологической помощи в Республике Башкортостан и пути ликвидации устранимой слепоты // Ликвидация устранимой слепоты: Всемирная инициатива ВОЗ: матер. Рос. межрегион. симп. М., 2003. С. 60—68.
  3. Маркелова Е.В., Хохлова А.С., Кириенко А.В., Филина Н.В., Серебрянная Н.Б. Особенности иммунопатогенеза и дополнительные дифференциальные маркеры первичной открытоугольной и первичной закрытоугольной глауком // Здоровье и образование в XXI веке. 2016. Т. 18, № 2. С. 613—621.
  4. Петров С.Ю., Антонов А.А., Макарова А.С., Вострухин С.В. Офтальмотонус в оценке медикаментозного и хирургического лечения глаукомы // Русский медицинский журнал. Клиническая офтальмология. 2015. Т. 16, № 2. С. 69—72.
  5. Слепова О.С., Арапиев М.У., Ловпаче Д.Н., Балацкая Н.В., Куликова И.Г. Особенности местного и системного цитокинового статуса у здоровых разного возраста и пациентов с начальной стадией первичной открытоугольной глаукомы // Национальный журнал глаукома. 2016. Т. 15, № 1. С. 3—12.
  6. Abcouwer S.F., Shanmugam S., Gomez P.F., Shushanov S., Barber A., Lanoue K., Quinn P., Kester M., Gardner T. Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons. Invest. Ophthalmol. Vis. Sci., 2008, vol. 49, no. 12, pp. 5581-5592. doi: 10.1167/iovs.07-1032
  7. Alexandrescu C., Dascalu A.M., Mitulescu C., Panca A., Ciuluvica R., Potop V., Voinea L. Evidence-based pathophysiology of glaucoma. Maedica, 2010, vol. 5, no. 3, pp. 207-213.
  8. Chua J., Vania M., Cheung C.M., Ang M., Chee S., Yang H., Li J., Wong T. Expression profile of inflammatory cytokines in aqueous from glaucomatous eyes. Molecular Vision, 2012, no. 18, pp. 431-438.
  9. Gibson D.M. Frequency and predictors of missed visits to primary care and eye care providers for annually recommended diabetes preventive care services over a two-year period among U.S. adults with diabetes. Prev. Med., 2017, vol. 105, pp. 257-264. doi: 10.1016/j.ypmed.2017.09.019
  10. Haddad M.F., Bakkar M.M., Abdo N. Public awareness of common eye diseases in Jordan. BMC Ophthalmol., 2017, no. 17:177. doi: 10.1186/s12886-017-0575-3
  11. Harrabi H., Kergoat M.J., Rousseau J., Boisjoly H., Schmaltz H., Moghadaszadeh S., Roy-Gagnon M.H., Freeman E.E. Age-related eye disease and cognitive function. Invest. Ophthalmol. Vis. Sci., 2015, vol. 56, no. 2, pp. 1217-1221. doi: 10.1167/iovs.14-15370
  12. Islam F.M., Chakrabarti R., Islam S.Z., Finger R.P., Critchley C. Factors associated with awareness, attitudes and practices regarding common eye diseases in the general population in a rural district in Bangladesh: the Bangladesh population-based diabetes and eye study (BPDES). PLoS One, 2015, vol. 10, no. 7: e0133043. doi: 10.1371/journal.pone.0133043
  13. Kass M.A., Gordon M.O., Gao F., Heuer D.K., Higginbotham E.J., Johnson C.A., Keltner J.K., Miller J.P., Parrish R.K., Wilson M.R. for the Ocular Hypertension Treatment Study Group. Delaying treatment of ocular hypertension: the ocular hypertension treatment study. Arch. Ophthalmol., 2010, vol. 128, no. 3, pp. 276-287. doi: 10.1001/archophthalmol.2010.20
  14. Katibeh M., Ziaei H., Panah E., Moein H.R. Knowledge and awareness of age related eye diseases: a population-based survey. J. Ophthalmic. Vis. Res., 2014, vol. 9, no. 2, pp. 223-231.
  15. Koeberle P.D., Gauldie J., Ball A.K. Effects of adenoviral-mediated gene transfer of interleukin-10, interleukin-4, and transforming growth factor-beta on the survival of axotomized retinal ganglion cells. Neuroscience, 2004, vol. 125, no. 4, pp. 903-920. doi: 10.1016/S0306-4522(03)00398-1
  16. Kolko M., Horwitz A., Thygesen J., Jeppesen J., Torp-Pedersen C. The Prevalence and incidence of glaucoma in Denmark in a fifteen year period: a nationwide study. PLoS One, 2015, vol. 10, no. 7: e0132048.
  17. Levkovitch-Verbin H., Goldshtein I., Chodick G., Zigman N., Shalev V. The Maccabi Glaucoma Study: prevalence and incidence of glaucoma in a large israeli health maintenance organization. Am. J. Ophthalmol., 2014, vol. 158, no. 2, pp. 402-408. doi: 10.1016/j.ajo.2014.04.026
  18. Napoli P.E., Sanna R., Iovino C., Fossarello M. Resolution of pinguecula-related dry eye disease after argon laser photocoagulation. Int. Med. Case Rep. J., 2017, no. 10, pp. 247-250. doi: 10.2147/IMCRJ.S138786
  19. Paul C., Sengupta S., Choudhury S. Prevalence of glaucoma in Eastern India: the hooghly river glaucoma study. Indian J. Ophthalmol,, 2016, vol. 64, no. 8, pp. 578-83. doi: 10.4103/0301-4738.191497
  20. Tham Y.C., Li X., Wong T.Y., Quigley H.A., Aung T., Cheng C.Y. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis. Ophthalmology, 2014, no. 121, pp. 2081-2090. doi: 10.1016/j.oph-tha.2014.05.013
  21. Zhao Y., Fu J.L., Li Y.L. Epidemiology and clinical characteristics of patients with glaucoma: an analysis of hospital data between 2003 and 2012. Indian J. Ophthalmol., 2015, vol. 63, no. 11, pp. 825—831.
  22. Zheng Y., Cheng C.Y., Lamoureux E.L., Chiang P.P., Rahman Anuar A., Wang J.J., Mitchell P., Saw S.M., Wong T.Y. How much eye care services do Asian populations need? Projection from the Singapore Epidemiology of Eye Disease (SEED) study. Invest. Ophthalmol. Vis. Sci., 2013, vol. 54, no. 3, pp. 2171—2177. doi: 10.1167/iovs.12-11393

Copyright (c) 2020 Chukhraiev A.M., Agarkov N.M., Konyaev D.A., Popova E.V., Yablokov M.M., Kulabukhov A.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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