Comparative prevalence of atopic sensitization in the border areas between Russia and Finland

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Current century has been highlighted with rise in allergic pathology, and environment markedly affects it via epigenetic mechanisms. Allergy research in Russia and Finland has been conducted for many years, of larger scale recorded in the latter, still being maintained over time. Atopy prevalence was studied in the border areas in both countries. The level of total, dietary, inhaled IgE level, as well as dietary and inhalation range were examined. The Phadiatop® radio allergen sorbent test was used (UniCAP 1000 v.2; Pharmacia Upjohn, Uppsala, Sweden), with cut-off point: IgE > 110 kUA/l and sIgE > 2.5 kUa/l and 0.35 kUA/l. The study was subdivided into 2 stages conducted during 2003 and 2010/2012 timeframe. Stage 1 was performed with children from Finland (n = 344), Russia (n = 427), aged 7—15 years, whereas stage 2 — 180 subjects (Finland, n = 98, Russia, n = 82). Results. It was found that total IgE level was higher in children from Finland. The inhaled sIgE in 2003 and 2010/2012 was higher among children from Finland, p = 0.019 and p = 0.027, showing temporal elevation. In 2003, dietary sIgE was higher among those from Finland (27.6% and 18.3%), p = 0.142, whereas in 2010/2012 it was decreased by 2- and 3-fold in subjects from Finland and Russia, respectively. In 2003, high atopy rate against dust mites, cats, timothy, birch, and dogs was found in Russia, which was increased at stage 2. Such parameter was most evidently elevated for timothy — by 2-fold, p = 0.176, wormwood — by 2-fold, p = 0.312, equine allergens — by 2-fold, p = 0.563, canine allergens — by 1.5-fold, mite — by 1.5-fold, p = 0.220. In 2003, atopy rate in Finland to canine allergens reached 26.5%, timothy — 24.5%, birch — 20.4%, feline allergens — 20.4%. In 2010, it was noted rise in atopy rate mainly to dust mites — by 2-fold, equine allergens — by 2-fold. In 2003, atopy rate in Russia to egg, milk, and wheat prevailed, whereas in Finland it was mostly found against milk, nuts, wheat, eggs, in both cases declined in dynamics. Interestingly, no sensitization to fish in subjects from Russia and Finland was observed at both stages. Finally, at the stage 2 dietary atopy rate was declined in both countries. Differences in atopic sensitization as well as during 7—9 year follow-up observation were preserved between both subject cohorts from Finland and Russia.

About the authors

O. A. Markelova

Petrozavodsk State University

Author for correspondence.
ORCID iD: 0000-0003-1291-6342

Olga A. Markelova - Pulmonologist, V.A. Baranov Republican Hospital, Petrozavodsk, Russian Federation; Employee of the Department of Hospital Therapy, Postgraduate Education in Pulmonology, Medical Institute of Petrozavodsk SU.

185019, Petrozavodsk, Pirogova str., 3, Phone: +7 911 410-31-34

Russian Federation

N. N. Vezikova

Petrozavodsk State University

ORCID iD: 0000-0002-8901-3363

PhD, MD (Medicine), Professor, Head of the Department of Hospital Therapy, Medical Institute of Petrozavodsk State University, Chief Therapist of the Ministry of Health of the Republic of Karelia.


Russian Federation

E. K. Zilber

St. Petersburg State Research Institute of Phthisiopulmonology of the Ministry of Healthcare of the Russian Federation


PhD, MD (Medicine), Leading Researcher.

St. Petersburg

Russian Federation


  1. Asher M.I., Montefort S., Bjorksten B., Lai C.K., Strachan D.P., Weiland S.K., Williams H., ISAAC Phase Three Study Group. Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet, 2006, vol. 368,pp. 733-743. doi: 10.1016/s0140-6736(06)69283-0
  2. Genuneit J., Seibold A.M., Apfelbacher C.J., Konstantinou G.N., Koplin J.J., La Grutta S., Logan K., Perkin M.R., Flohr C. Overview of systematic reviews in allergy epidemiology. Allergy, 2017, vol. 72, iss. 6. doi: 10.1111/all.13123
  3. Haahtela T., Laatikainen T., Alenius H., Auvinen P., Fyhrquist N., Hanski I., Hertzen L., Jousilahti P, Kosunen T., Markelova O., Makela M., Pantelejev V., Uhanov M., Zilber E., Vartiainen E. Hunt for the origin of allergy — comparing the Finnish and Russian Karelia. J. Clin. Exp. All., 2015, vol. 45, pp. 891-901. doi: 10.1111/cea.12527
  4. Laatikainen T., von Hertzen L., Koskinen J.P., Makela M.J., Jousilahti P.,Kosunen T.U., Vlasoff T., Ahlstrom M., Vartiainen E., Haahtela T. Allergy gap between Finnish and Russian Karelia on increase. Allergy, 2011, vol. 66, pp. 886-892. doi: 10.1111/j.1398-9995.2010.02533.x
  5. Pawankar R., Canonica G.W., Holgate S., Lockey R.F. WAO White Book on Allergy 2011-2012: Executive Summary. World Allergy Organization (WAO), 2011. doi: 10.1163/1570-6664_iyb_sim_org_38984
  6. Pekkarinen PT., von Hertzen L., Laatikainen T., Makela M. J, Jousilahti P, Kosunen T.U., Pantelejev V., Vartiainen E., Haahtela T. A disparity in the association of asthma, rhinitis, and eczema with allergen-specific IgE between Finnish and Russian Karelia. Allergy, 2007, vol. 62, pp. 281-287. doi: 10.1111/j.1398-9995.2006.f)1249.x
  7. Prescott S.L. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J. All. Clin. Imm., 2013, vol. 131, pp. 23-30. doi: 10.1016/j.jaci.2012.11.019
  8. Riedler J., Braun-Fahrlander C., Eder W., Schreuer M., Waser M., Maisch S., Carr D., Schierl R., Nowak D., von Mutius E. Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet, 2001, vol. 358, pp. 11291133. doi: 10.1016/s0140-6736(01)06252-3
  9. Ruokolainen L., Paalanen L., Karkman A., Laatikainen T., von Hertzen L., Vlasoff T., Markelova O., Masyuk V., Auvinen P., Paulin L., Alenius H., Fyhrquist N., Hanski I., Makela M.J., Zilber E., Jousilahti P., Vartiainen E., Haahtela T. Epidemiology of allergic disease. Significant disparities in allergy prevalence and microbiota between the young people in Finnish and Russian Karelia. J. Clin. Exp. All., 2017, vol. 47, iss. 5, pp. 665-674. doi: 10.1111/cea.12895
  10. Von Hertzen L., Makela M.J, Petays T., Jousilahti P., Kosunen T.U., Laatikainen T., Vartiainen E., Haahtela T. Growing disparities in atopy between the Finns and the Russians: a comparison of 2 generations. J. Allergy Clin. Imm., 2006, vol. 117, pp. 151-157. doi: 10.1016/j.jaci.2005.07.028
  11. Von Mutius E., Vercelli D. Farm living: effects on childhood asthma and allergy. Nat. Rev. Immunol., 2010, vol. 10, pp. 861-868. doi: 10.1038/nri2871

Copyright (c) 2020 Markelova O.A., Vezikova N.N., Zilber E.K.

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