Cover Page

Cite item


Abstract. The study was performed in the Perm Krai Clinical Hospital N 2 “Heart Institute”. The aim of this study was to evaluate the antibiotic susceptibility in isolates from patients with diabetes mellitus and HIV-infected patients. In all groups involved in the study (patients with diabetes mellitus, patients with HIV infection, and control group) the predomination of the Gram-positive species have been revealed. This fact is typical for surgical departments. More isolates of Staphylococcus aureus were found in the group of HIV-infected patients compared to patients in the control group (20.6% vs 4.6%, p = 0.02, respectively). Oxacillin resistance rate in Staphylococcus aureus was higher in the group of HIV-infected patients than in patients from the control group. Significant differences in Staphylococcus epidermidis resistance rate between HIV-infected patients and patients in the control group were detected for oxacillin (60% vs 10%, p = 0.03, respectively). It is plausible that in the group of immunocompromised patients vancomycin might be recommended for empiric therapy of infections caused by gram-positive species. The Enterococcus faecalis was more often isolated from HIV-infected patients in compare with patients from the control group (34.5% vs 13.8%, p = 0.02), probably due to severe immunodeficiency in the late stages of HIV infection. The absence of significant differences in resistance rate in Staphylococcus aureus and Staphilococcus epidermidis between patients with diabetes and patients in the control group could be considered as important. This fact might be associated with judicious control of glycemia during the pre-, intra-, and postoperative time periods. Postoperative pyoinflammatory diseases remain serious obstacle for the progress in cardiosurgery. Consequently, it’s important to know the characteristics of the microflora, colonizing the patients.

About the authors

A. Yu. Yagodina

ГБУЗ Пермского края Пермская краевая клиническая больница № 2 «Институт Сердца», г. Пермь

Author for correspondence.

к.м.н., врач-инфекционист

614016, г. Пермь, ул. Елькина, 47, кв. 6

Russian Federation

O. G. Pegushina

ГБУЗ Пермского края Пермская краевая клиническая больница № 2 «Институт Сердца», г. Пермь

Russian Federation

Yu. N. Maslov

ГБОУ ВПО Пермская государственная медицинская академия им. акад. Е.А. Вагнера МЗ РФ, г. Пермь

Russian Federation

I. A. Serova

ГБОУ ВПО Пермская государственная медицинская академия им. акад. Е.А. Вагнера МЗ РФ, г. Пермь

Russian Federation

S. A. Naumov

ГБУЗ Пермского края Пермская краевая клиническая больница № 2 «Институт Сердца», г. Пермь

Russian Federation


  1. Алборов А.Х., Колосовская Е.Н., Калинина З.П., Савушкин Ю.Н., Новиков В.Д. Основные результаты и нерешенные задачи реализации системы эпидемиологического наблюдения в стационарах хирургического профиля // Инфекция и иммунитет. — 2012. — № 1–2: Итоги и перспективы обеспечения эпидемиологического благополучия населения Российской Федерации: материалы X съезда Всерос. науч.-практ. о-ва эпидемиологов, микробиологов и паразитологов. — С. 470.
  2. Мерзлова Н.Б., Серова И.А., Ягодина А.Ю. Проблема изменения стереотипов оказания медицинской помощи в России на основе международной классификации функционирования, инвалидности и здоровья // Фундаментальные исследования. — 2012. — № 7 (Часть 1). — С. 135–139.
  3. Acharya M.N., Som R., Tsui S. What is the optimum antibiotic prophylaxis in patients undergoing implantation of a left ventricular assist device? // Interact. Cardiovasc. Thorac. Surg. — 2012. — Vol. 14, N 2. — P. 209 –214.
  4. Gonçalves L.S., Soares Ferreira S.M., Souza C.O., Souto R., Colombo A.P. Clinical and microbiological profiles of human immunodeficiency virus (HIV)-seropositive Brazilians undergoing highly active antiretroviral therapy and HIV-seronegative Brazilians with chronic periodontitis // J. Periodontol. — 2007. — Vol. 78, N 1. — P. 87–96.
  5. Hodgkiss-Harlow K.D., Bandyk D.F. Antibiotic therapy of aortic graft infection: treatment and prevention recommendations // Semin. Vasc. Surg. — 2011. — Vol. 24, N 4. — P. 191–198.
  6. Kutlu S.S., Cevahir N., Akalin S., Akin F., Dirgen Caylak S., Bastemir M., Tekin K. Prevalence and risk factors for methicillin-resistant Staphylococcus aureus colonization in a diabetic outpatient population: a prospective cohort study // Am. J. Infect. Control. — 2012. — Vol. 40, N 4. — P. 365–368.
  7. Manfredi R., Nanetti A., Valentini R., Calza L., Chiodo F. Frequency, epidemiology, risk factors, clinical and bacteriological features of enterococcal disease in patients with HIV infection in a deca de survey // New Microbiol. — 2002. — Vol. 25, N 2. — P. 179–186.
  8. Marie S. de. Diseases and drug-related interventions affecting host defence // Eur. J. Clin. Microbiol. Infect. Dis — 1993. — Vol. 12 (Suppl.1). — P. 36–41.
  9. Petrovici C.G., Dorobăţ C., Matei M., Teodor A., Luca V., Miftode E. Aspects of the antimicrobial resistence profile in infections with Escherichia coli and Klebsiella pneumoniae in diabetic patients // Rev. Med. Chir. Soc. Med. Nat. Iasi. — 2011 — Vol. 115, N 3. — P. 769–775.
  10. Popov A., Zverev S., Maslov Y., Sharybina N. High frequency of methicillin-resistant staphylococci detection at post-injecting pioinflammatory complications in HIV-infected injecting drug users XVIII International AIDS Conference, July 18–23, 2010, Vienna, Austria. CDB0091.
  11. Shadyab A., Crum-Cianflone N. Methicillin-resistant Staphylococcus aureus (MRSA) infections among HIV-infected persons in the era of highly active antiretroviral therapy: a review of the literature // HIV Med. — 2012. — Vol. 13, N 6. — P. 319–332.
  12. Sharma M., Fakih M.G., Berriel-Cass D., Meisner S., Saravolatz L., Khatib R. Harvest surgical site infection following coronary artery bypass grafting: risk factors, microbiology, and outcomes // Am. J. Infect. Control. — 2009. — Vol. 37, N 8. — P. 653–657.

Copyright (c) 2014 Yagodina A.Y., Pegushina O.G., Maslov Y.N., Serova I.A., Naumov S.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies