Enterovirus infection in the Socialist Republic of Vietnam

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Abstract

Human enterovirus infections comprise a group of infectious diseases caused by viruses of Enterovirus A-D species (genus Enterovirus, family Picornaviridae). Enterovirus infections can vary in clinical manifestations and severity, from asymptomatic infection to serious multisystem diseases. During evolution, enterovirus strains with increased neurovirulence or atypical pathogenicity may emerge exhibiting an epidemic potential. Recently, outbreaks of enterovirus infection with an increased rate of neurological manifestations, a significant percentage of severe cases and lethal outcomes have been observed worldwide, which were associated with enteroviruses EV-A71, EV-D68 etc. The World Health Organization has included EV-A71 and EV-D68 enterovirus infection together with some other dangerous viral diseases considered for inclusion in the List of Blueprint Priority Diseases. In connection with this, global enterovirus surveillance is important for controlling emergence and spread of epidemic enterovirus variants, prediction of establishing epidemic situation, timely conduction of preventive measures and vaccine development. A growing multi-field cooperation between Russia and Vietnam leads to increased two-way population migration, which actualizes scientific and practical collaboration in surveillance and control of infectious disease spread, including enterovirus infection. Currently, epidemiological surveillance of enterovirus infection in Vietnam is based on monitoring hand, foot and mouth disease (HFMD) rate, laboratory diagnostics of enterovirus infection and identification of enterovirus strains, mainly detected in severe patients. In 2001–2016, 34 non-polio virus types were identified in patients with enterovirus infection, largely represented by viruses EV-A71, CVA6, CVA10, and CVA16. Moreover, the peak incidence of enterovirus infection and related mortality rate were associated with the increased activity of EV-A71 virus. In Vietnam, EVA71 enterovirus of genotypes C1, C4, C5 and B5 circulated at different times. Over the last years, a new pandemic genotype virus CVA6 has been dominating as a causative agent of enterovirus infection in Vietnam as well as the majority of other countries. The data on phylogenetic relation between Vietnamese epidemic EV-A71 and CVA6 strains allowed to find that they underwent multiple betweencountry spreads, whereas their subsequent in-country dissemination resulted in 2011–2012 enterovirus outbreak and sustained high-level HFMD morbidity.

About the authors

L. N. Golitsyna

Blokhina Nizhny Novgorod Research institute of Epidemiology and Microbiology

Author for correspondence.
Email: lyudmila_galitzina@mail.ru

PhD (Medicine), Leading Researcher, Laboratory of Molecular Epidemiology of Viral Infections,

603950, Nizhny Novgorod, Malaya Yamskaya, 71

Россия

T. T.T. Nguyen

Pasteur Institute of Ho Chi Minh City

Email: tthao1103@yahoo.com

PhD (Medicine), Head of the Laboratory of Enteroviruses, Department of Immunology and Microbiology,

Ho Chi Minh City

Вьетнам

N. I. Romanenkova

St. Petersburg Pasteur Institute

Email: romanenkova@pasteurorg.ru

PhD (Medicine), Senior Researcher, Leading Researcher Laboratory of Etiology and Control of Viral Infections,

St. Petersburg

Россия

M. T. Luong

Russian-Vietnamese Tropical research and technology center, South branch

Email: fake@neicon.ru

PhD (Chemistry), Head of the Laboratory Tropical Biomedicine,

Ho Chi Minh City

Вьетнам

L. T. Vu

Russian-Vietnamese Tropical research and technology center, Head office

Email: vtloan194@gmail.com

PhD (Biology), Deputy Head of Pharmacy Laboratory,

Hanoi

Вьетнам

O. I. Kanaeva

St. Petersburg Pasteur Institute

Email: ol.kanaeva@gmail.com

Researcher, Laboratory of Etiology and Control of Viral Infections,

St. Petersburg

Россия

M. A. Bichurina

St. Petersburg Pasteur Institute

Email: romanenkova@pasteurorg.ru

PhD, MD (Medicine), Head of the Laboratory of Etiology and Control of Viral Infections,

St. Petersburg

Россия

N. A. Novikova

Blokhina Nizhny Novgorod Research institute of Epidemiology and Microbiology

Email: mevirfc@rambler.ru

PhD, MD (Biology), Professor, Head of the Laboratory of Molecular Epidemiology of Viral Infections,

Nizhny Novgorod

Россия

References

  1. Голицына Л.Н., Зверев В.В., Парфенова О.В., Епифанова Н.В., Сашина Т.В., Кашников А.Ю., Григорьева Г.И., Новикова Н.А. Вирус Коксаки А6 в Российской Федерации в 2014 году // Дальневосточный журнал инфекционной патологии. 2015. № 28. С. 12–20.
  2. Голицына Л.Н., Зверев В.В., Парфенова О.В., Новикова Н.А. Эпидемические варианты неполиомиелитных энтеровирусов в России // Медицинский альманах. 2015. Т. 40, № 5. С. 136–140.
  3. Лукашев А.Н., Голицына Л.Н., Вакуленко Ю.А., Ахмадишина Л.В., Романенкова Н.И., Сапега Е.Ю., Морозова Н.С., Новикова Н.А., Троценко О.Е., Иванова О.Е. Современные возможности и направления развития молекулярноэпидемиологического мониторинга в надзоре за энтеровирусными инфекциями. Опыт Российской Федерации // Инфекция и иммунитет. 2018. Т. 8, № 4. С. 452–464. doi: 10.15789/2220-7619-2018-4-452-464 (In Russ.)
  4. Романенкова Н.И., Голицына Л.Н., Бичурина М.А., Розаева Н.Р., Канаева О.И., Зверев В.В., Созонов Д.В., Черкасская И.В., Кириллова Л.П., Ермакова М.В., Камынина Л.С., Петухова М.Б., Грицай А.Б., Новикова Н.А. Заболеваемость энтеровирусной инфекцией и особенности циркуляции неполиомиелитных энтеровирусов на некоторых территориях России в 2017 году // Журнал инфектологии. 2018. Т. 10, № 4. С.124–133. doi: 10.22625/2072-6732-2018-10-4-124-133 (In Russ.)
  5. Шишко Л.А., Романенкова Н.И., Бичурина М.А., Гордиенко Т.А., Розаева Н.Р., Голицына Л.Н., Фомина С.Г., Канаева О.И., Лялина Л.В., Новикова Н.А. Этиология сезонных подъемов заболеваемости энтеровирусной инфекцией в Архангельской области // Инфекция и иммунитет. 2013. Т. 3, № 1. С. 65–72. doi: 10.15789/2220-7619-2013-1-65-72 (In Russ.)
  6. Anh N.T., Nhu L.N.T., Van H.M.T., Hong N.T.T., Thanh T.T., Hang V.T.T., Ny N.T.H., Nguyet L.A., Phuong T.T.L., Nhan L.N.T., Hung N.T., Khanh T.H., Tuan H.M., Viet H.L., Nam N.T., Viet D.C., Qui P.T., Wills B., Sabanathan S., Chau N.V.V., Thwaites L., van Doorn H.R., Thwaites G., Rabaa M.A., Van Tan L. Emerging Coxsackievirus A6 causing hand, foot and mouth disease, Vietnam. Emerg. Infect. Dis., 2018, vol. 24, no. 4, pp. 654–662. doi: 10.3201/eid2404.171298
  7. B’Krong N.T.T.C., Minh N.N.Q., Qui P.T., Chau T.T.H., Nghia H.D.T., Do L.A.H., Nhung N.N., van Vinh Chau N., Thwaites G., van Tan L., van Doorn H.R., Thanh T.T.. Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997–2010. Virol. J., 2018, vol. 15, no. 69, pp. 1–8. doi: 10.1186/s12985-018-0980-0
  8. Broberg E.K., Simone B., Jansa J., The EU/EEA Member State Contributors. Upsurge in echovirus 30 detections in five EU/EEA countries, April to September, 2018. Euro Surveill., 2018, vol. 23, no. 44. doi: 10.2807/1560-7917.ES.2018.23.44.1800537
  9. Dao T.H.N., Nguyen T.A, Nguyen T.H.T. Tran N.D., Ngu D.N., Tran N.T., Tran T.N.H. Re-emergence of enterovirus 71 subgenogroup C4a associated with hand foot and mouth disease in northern provinces, Vietnam, 2016–2018. Vietnam J. Prevent. Med., 2018, vol. 28, no. 7, p. 115.
  10. Do A.H., van Doorn H.R., Nghiem M.N., Bryant J.E., Hoang T.H., Do Q.H., Van T.L., Tran T.T., Wills B., Nguyen V.C., Vo M.H., Vo C.K., Nguyen M.D., Farrar J., Tran T.H., de Jong M.D. Viral etiologies of acute respiratory infections among hospitalized Vietnamese children in Ho Chi Minh City, 2004–2008. PLoS One, 2011, vol. 6, no. 3: e18176. doi: 10.1371/journal.pone.0018176
  11. Do L.A., Bryant J.E., Tran A.T., Nguyen B.H., Tran T.T., Tran Q.H., Vo Q.B., Tran Dac N.A., Trinh H.N., Nguyen T.T., Le Binh B.T., Le K., Nguyen M.T., Thai Q.T., Vo T.V., Ngo N.Q., Dang T.K., Cao N.H., Tran T.V., Ho L.V., Farrar J., de Jong M., van Doorn H.R. Respiratory syncytial virus and other viral infections among children under two years old in Southern Vietnam 2009–2010: clinical characteristics and disease severity. PLoS One, 2016, vol. 11, no. 8: e0160606. doi: 10.1371/journal.pone.0160606
  12. Donato C., Le T.H., Nguen T.H., Tran M.H., Le V.D., Ta T.D.N., Nguen V.K., Nguen V.T., Vijaykrishna D. Genetic characterization of Enterovirus 71 strains circulating in Vietnam in 2012. Virology, 2016, vol. 495, pp. 1–9. doi: 10.1016/j.virol.2016.04.026
  13. Geoghegan J.L., Tan le V., Kühnert D., Halpin R.A., Lin X., Simenauer A., Akopov A., Das S.R., Stockwell T.B., Shrivastava S., Ngoc N.M., Uyen le T.T., Tuyen N.T., Thanh T.T., Hang V.T., Qui P.T., Hung N.T., Khanh T.H., Thinh le Q., Nhan le N.T., Van H.M., Viet do C., Tuan H.M., Viet H.L., Hien T.T., Chau N.V., Thwaites G., Grenfell B.T., Stadler T., Wentworth D.E., Holmes E.C., Van Doorn H.R. Phylodynamics of Enterovirus A71-associated hand, foot, and mouth disease in Viet Nam. J. Virol., 2015, vol. 89, no. 17, pp. 8871–8879. doi: 10.1128/JVI.00706-15
  14. Greninger A.L., Naccache S.N., Messacar K., Clayton A., Yu G., Somasekar S., Federman S., Stryke D., Anderson C., Yagi S., Messenger S., Wadford D., Xia D., Watt J.P., Van Haren K., Dominguez S.R., Glaser C., Aldrovandi G., Chiu C.Y. A novel outbreak enterovirus D68 strain associated with acute flaccid myelitis cases in the USA (2012–14): a retrospective cohort study. Lancet Infect. Dis., 2015, vol. 15, no. 6, pp. 671–682. doi: 10.1016/S1473-3099(15)70093-9
  15. Hoang M.T.V., Nguyen T.A., Tran T.T., Vu T.T.H., Le N.T.N., Nguyen T.H.N., Le T.H.N., Nguyen T.T.H., Nguyen T.H., Le N.T.N., Truong H.K., Du T.Q., Ha M.T., Ho L.V., Do C.V., Nguyen T.N., Nguyen T.M.T., Sabanathan S., Phan T.Q., Nguyen Van V.C., Thwaites G.E., Wills B., Thwaites C.L., Le V.T., van Doorn H.R. Clinical and aetiological study of hand, foot and mouth disease in southern Vietnam, 2013–2015: inpatients and outpatients. Int. J. Infect. Dis., 2019, vol. 80, pp. 1–9. doi: 10.1016/j.ijid.2018.12.00
  16. Khanh T.H., Sabanathan S., Thanh T.T., Thoa le P.K., Thuong T.C., Hang Vt., Farrar J., Hien T.T., van Vinh Chau N., van Doorn H.R. Enterovirus 71-associated hand, foot, and mouth disease, Southern Vietnam, 2011. Emerg. Infect. Dis., 2012, vol. 18, no. 12, pp. 2002–2005. doi: 10.3201/eid1812.120929
  17. Le T.V., Nguyen V.T.T., Nguyen Q.H., Pham D.T. Molecular epidemiology analysis of enterovirus 71 strains isolated in Dak Lak, Vietnam, 2011–2016. J. Med. Virol., 2019, vol. 91, pp. 56–64. doi: 10.1002/jmv.25286
  18. Lugo D., Krogstad P. Enteroviruses in the early 21st century: new manifestations and challenges. Curr. Opin. Pediatr., 2016, vol. 28, no. 1, pp. 107–113. doi: 10.1097/MOP.0000000000000303
  19. Messacar K., Schreiner T.L., Maloney J.A., Wallace A., Ludke J., Oberste M.S., Nix W.A., Robinson C.C., Glodé M.P., Abzug M.J., Dominguez S.R. A cluster of acute flaccid paralysis and cranial nerve dysfunction temporally associated with an outbreak of enterovirus D68 in children in Colorado, USA. Lancet, 2015, vol. 385, pp. 1662–1671. doi: 10.1016/S0140-6736(14)62457-0
  20. Nguyen D.N.T., Mai L.Q., Bryant J.E., Hang N.L.K., Hoa L.N.M., Nadjm B., Thai P.Q., Duong T.N., Anh D.D., Horby P., van Doorn H.R., Wertheim H.F.L., Fox A. Epidemiology and etiology of influenza-like-illness in households in Vietnam; it’s not all about the kids! J. Clin. Virol., 2016, vol. 82, pp. 126–132. doi: 10.1016/j.jcv.2016.07.014
  21. Nguyen N.T., Pham H.V., Hoang C.Q., Nguyen T.M., Nguyen L.T., Phan H.C., Phan L.T., Vu L.N., Tran Minh N.N. Epidemiological and clinical characteristics of children who died from hand, foot and mouth disease in Vietnam, 2011. BMC Infect. Dis., 2014, vol. 14, no. 341, pp. 1–7. doi: 10.1186/1471-2334-14-341
  22. Nguen T.H.N., Anh N.T., Hang V.T.T., Nguyet L.A., Thanh T.T., Ha D.Q., Minh N.N.Q., Ha D.L.A., McBride A., Tuan H.M., Baker S., Tam P.T.T., Phuc T.M., Huong D.T., Loi T.Q., Vu N.T.A., Hung N.V., Minh T.T.T., Xang N.V., Dong N., Nghia H.D.T., Chau N.V.V., Thwaites G., van Doorn H.R., Anscombe C., Le Van T.; VIZIONS Consortium. Enterovirus 68 in Vietnam (2009– 2015). Wellcome Open Res., 2017, vol. 2, no. 41, pp. 1–17. doi: 10.12688/wellcomeopenres.11558.2
  23. Nguen T.T.T., Donato C., Trang V.T.H., Kien N.T., Trang P.M.M.T., Khanh T.Q., Nguyet D.T., Sessions O.M., Cuong H.Q., Lan P.T., Huong V.T.Q., van Doorn H.R., Vijaykrishna D. Evolution and spatiotemporal dynamics of enterovirus A71 subgenogroups in Vietnam. J. Infect. Dis., 2017, vol. 216, no. 11, pp. 1371–1379. doi: 10.1093/infdis/jix500
  24. Nguen T.T.T., Vu T.H.T., Nguen T.K., Pham M.T.T., Tran Q.K., Hoang Q.C. Circulation of Coxsackievirus A in hand-foot-mouth disease in Southern Vietnam 2015–2016. Russian Jornal of Infection and Immunity, 2018, vol. 8, no. 4, p. 533. doi: 10.15789/2220-7619-2018-4-3.35
  25. Nhan L.N.T., Hong N.T.T., Nhu L.N.T., Nguyet L.A., Ny N.T.H., Thanh T.T., Han D.D.K., Van H.M.T., Thwaites C.L., Hien T.T., Qui P.T., Quang P.V., Minh N.N.Q., van Doorn H.R., Khanh T.H., Chau N.V.V., Thwaites G., Hung N.T., Tan L.V. Severe enterovirus A71 associated hand, foot and mouth disease, Vietnam, 2018: preliminary report of an impending outbreak. Euro Surveill., 2018, vol. 23, no. 46, pp. 1–5. doi: 10.2807/1560-7917.ES.2018.23.46.1800590
  26. Phan C.H., Nguyen T.P.T., Doan N.M.Q., Nguyen T.T.T., Nguyen Q.H., Tran A.T., Nguyen Q.K., Kiem S.H., Hoang T.L., Vu T.H.T., Nguyen T.K., Phan T.L. Epidemiological characteristic of hand, foot and mouth disease in the south of Vietnam, 2010–2012. Vietnam. J. Prevent. Med., 2013, vol. 23, no. 10, p. 172.
  27. Phan N.T., Gouilh M.A., Paireau J., Phuong L., Cheval J., Ngu N.D., Hébert C., Nguyen T.H., Lortholary O., Tondeur L., Manuguerra J.C., Barouki R., Sander J., Janzen N., Nguyen H.T., Brey P.T., Fontanet A., Eloit M. Hypoglycemic toxins and enteroviruses as causes of outbreaks of acute encephalitis-like syndrome in children, Bac Giang province, Northern Vietnam. Emerg. Infect. Dis., 2018, vol. 24, no. 8, pp. 1435–1443. doi: 10.3201/eid2408.171004
  28. Phan V.T., Nguen T.T.T., Perera D., Truong K.H., Tien N.T.K., Thuong T.C., How O.M., Cardosa M.J., McMinn P.C. Epidemiologic and virologic investigation of hand, foot, and mouth disease, southern Vietnam, 2005. Emerg. Infect. Dis., 2007, vol. 13, no. 11, pp. 1733–1741. doi: 10.3201/eid1311.070632
  29. Puenpa J., Vongpunsawad S., Österback R., Waris M., Eriksson E., Albert J., Midgley S., Fischer T.K., Eis-Hübinger A.M., Cabrerizo M., Gaunt E., Simmonds P., Poovorawan Y. Molecular epidemiology and the evolution of human coxsackievirus A6. J. Gen. Virol., 2016, vol. 97, no. 12, pp. 3225–3231. doi: 10.1099/jgv.0.000619
  30. Tan le V., Thai le H., Phu N.H., Nghia H.D., Chuong L.V., Sinh D.X., Phong N.D., Mai N.T., Man D.N., Hien V.M., Vinh N.T., Day J., Chau N.V., Hien T.T., Farrar J., de Jong M.D., Thwaites G., van Doorn H.R., Chau T.T. Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years. PLoS Negl. Trop. Dis., 2014, vol. 8, no. 8, pp. 1–11. doi: 10.1371/journal.pntd.0003127
  31. Tan le V., Tuyen N.T., Thanh T.T., Ngan T.T., Van H.M., Sabanathan S., Van T.T., Thanh le T.M., Nguyet L.A., Geoghegan J.L., Ong K.C., Perera D., Hang V.T., Ny N.T., Anh N.T., Ha do Q., Qui P.T., Viet do C., Tuan H.M., Wong K.T., Holmes E.C., Chau N.V., Thwaites G., van Doorn H.R. A generic assay for whole-genome amplification and deep sequencing of enterovirus A71. J. Virol. Meth., 2015, vol. 215–216, pp. 30–36. doi: 10.1016/j.jviromet.2015.02.011
  32. Taylor W.R., Nguyen K., Nguyen D., Nguyen H., Horby P., Nguyen H.L., Lien T., Tran G., Tran N., Nguyen H.M., Nguyen T., Nguyen H.H., Nguyen T., Tran G., Farrar J., de Jong M., Schultsz C., Tran H., Nguyen D., Vu B., Le H., Dao T., Nguyen T., Wertheim H. The spectrum of central nervous system infections in an adult referral hospital in Hanoi, Vietnam. PLoS One, 2012, vol. 7, no. 8, pp. 1–8. doi: 10.1371/journal.pone.0042099
  33. Thoa le P.K., Chiang P.S., Khanh T.H., Luo S.T., Dan T.N., Wang Y.F., Thuong T.C., Chung W.Y., Hung N.T., Wang J.R., Nhan le N.T., Thinh le Q., Su I.J., Dung T.D., Lee M.S. Genetic and antigenic characterization of enterovirus 71 in Ho Chi Minh City, Vietnam, 2011. PLoS One, 2013, vol. 8, no. 7, pp. 1–6. doi: 10.1371/journal.pone.0069895
  34. Tran T.N.H., Nguen T.A.D, Dao T.H.A., Nguen T.T.T., Vu M.H., Nguen T.H.T. Enteroviruses associated with hand foot and mouth disease in the North of Vietnam, 2015–2016. Vietnam J. Prevent. Med., 2017, vol. 27, no. 8, p. 492.
  35. Van Pham H., Hoang T.N.A., Duong H.T., Phan L.T., Phan U.T.N., Ho N.X., Hoang C.Q. Clinical characteristics of hand, foot and mouth disease in Daklak Province, Vietnam and associated factors of severe cases. VirusDisease, 2017, vol. 28, no. 4, pp. 430–433. doi: 10.1007/s13337-017-0402-8
  36. World Health Organization. A guide to clinical management and public health response for hand, foot and mouth disease. 2011 [cited 29 March 2019]. URL: https://iris.wpro.who.int/bitstream/handle/10665.1/5521/9789290615255_eng.pdf
  37. World Health Organization. Disease surveillance – archives. Hand, Foot and Mouth Disease [cited 29 March 2019]. URL: https:// www.who.int/westernpacific/emergencies/surveillance/archives
  38. World Health Organization. List of Blueprint Priority Diseases. February 2018 — Second Annual Review [cited 29 March 2019]. URL: https://www.who.int/blueprint/priority-diseases/en
  39. Zell R., Delwart E., Gorbalenya A.E., Hovi T., King A.M.Q., Knowles N.J., Lindberg A.M., Pallansch M.A., Palmenberg A.C., Reuter G., Simmonds P., Skern T., Stanway G., Yamashita T. and ICTV Report Consortium. ICTV Virus Taxonomy Profile: Picornaviridae. J. Gen. Virol., 2017, vol. 98, no. 10, pp. 2421–2422. doi: 10.1099/jgv.0.000911

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Copyright (c) 2019 Golitsyna L.N., Nguyen T.T., Romanenkova N.I., Luong M.T., Vu L.T., Kanaeva O.I., Bichurina M.A., Novikova N.A.

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