Pattern of resilient age-related measles immunity

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Abstract

Epidemiological situation describing global measles spread is ambiguous. Along with countries succeeded in measles eradication, there are those wherein measles rate remains at quite high level. Because measles is a vaccine-preventable infection, it may then be eradicated solely by ensuring sufficient population coverage with preventive vaccination. The aim of our study was to assess level of measles immunity in medical workers at the Clinics of Samara State Medical University as well as the Samara State Medical University. There were enrolled 1503 subjects (aged 18–79 years), among which all individuals under 55 (77.58%) but not older counterparts provided with medical record on previous measles vaccination or measles infection. Level of serum measles virus-specific IgG antibodies was measured by using ELISA (VektoKor-IgG, JSC Vector-Best, Novosibirsk), with mean concentration ranging in general population within 1.02±0.02 IU/ ml. Positive results were observed in 72.52% of the examined individuals. Average vs. high measles virus-specific IgG level was detected in 52.90% (mean age — 41.4±0.5 years) and 19.62% (mean age — 54.2±0.72 years) of individuals, whereas at level below threshold — in 27.48% of subjects (mean age — 33.25±0.53 years). Thus, in 34.16% of the surveyed vaccinated individuals mostly presented by young subjects contained anti-measles virus-specific antibodies below protective level. Older age groups were shown to increase in average IgG amount with age. Interestingly, age-related measles immunity pattern was observed: percentage of subjects with high vs. low measles virus-specific IgG level increases and decreases, respectively. Taking into consideration a large percentage of subjects previously vaccinated against measles among carriers of low measles immunity, it may be concluded that measles virus-specific IgG antibody level must be monitored in young adulthood to decide of whether subsequent revaccination is necessary.

About the authors

A. G. Sonis

Samara State Medical University of MH RF; Clinics of Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-2148-6754

PhD, MD (Medicine), Professor, Vice Rector for Clinical Work, Head of the Department of General Surgery, Samara State Medical University; Medical Director, Clinics of Samara State Medical University

Samara

Россия

O. A. Gusyakova

Samara State Medical University of MH RF; Clinics of Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-5619-4583

PhD, MD (Medicine), Head of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics, Samara State Medical University; Head of the Clinical and Diagnostic Laboratory, Clinics of Samara State Medical University

Samara

Россия

F. N. Gilmiyarova

Samara State Medical University of MH RF

Email: bio-sam@yandex.ru
ORCID iD: 0000-0001-5992-3609

Honored Worker of Science of the Russian Federation, PhD, MD (Medicine), Professor of the Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics

Samara

Россия

A. A. Ereshchenko

Samara State Medical University of MH RF; Clinics of Samara State Medical University

Author for correspondence.
Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-4221-4440

Alena A. Ereshchenko, Assistant Professor, Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics, Samara State Medical University; Pathologist, Clinics of Samara State Medical University

443099, Samara, Chapayevskaya str., 89, Samara State Medical University
Phone: +7 (846) 337-04-63 (office)

Россия

N. K. Ignatova

Samara State Medical University of MH RF; Clinics of Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0003-1547-2150

PhD (Medicine), Associate Professor, Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics, Samara State Medical University; Pathologist, Clinics of Samara State Medical University

Samara

Россия

V. I. Kuzmicheva

Samara State Medical University of MH RF

Email: bio-sam@yandex.ru
ORCID iD: 0000-0002-5232-1549

Resident Physician, Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics

Samara

Россия

I. A. Borodina

Samara State Medical University of MH RF

Email: bio-sam@yandex.ru
ORCID iD: 0000-0001-7115-6430

Resident Physician, Department of Fundamental and Clinical Biochemistry with Laboratory Diagnostics

Samara

Россия

S. S. Nenjajkin

Clinics of Samara State Medical University

Email: bio-sam@yandex.ru
ORCID iD: 0000-0001-8797-6062

Head of The Department of Infectious Safety and Hygiene, Epidemiologist

Samara

Россия

References

  1. ВОЗ. 7-е совещание Европейской региональной комиссии по верификации элиминации кори и краснухи (РКВ); июнь 13–15, 2018 г. Париж, Франция.
  2. ВОЗ. Коревые вакцины: документ по позиции ВОЗ.
  3. Ноздрачева А.В., Грицик А.А., Кузин С.Н., Семененко Т.А. Оценка фактической восприимчивости отдельных групп декретированного населения к вирусам кори, краснухи и эпидемического паротита // Вестник РГМУ. 2017. № 5. С. 58–62. doi: 10.24075/brsmu.2017-05-05
  4. Об утверждении национального календаря профилактических прививок и календаря профилактических прививок по эпидемическим показаниям: Приказ Министерства здравоохранения РФ от 21 марта 2014 г. № 125н.
  5. О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2017 году: государственный доклад.
  6. Программа «Элиминация кори и краснухи в Российской Федерации» (2016–2020 гг.) (утверждена Роспотребнадзором 28.12.2015, Минздравом России 31.12.2015).
  7. Сармометов Е.В., Мокова Н.М., Вольдшмидт Н.Б., Сергевнин В.И., Цвиркун О.В., Метелкина Н.А. Оценка напряженности противокоревого иммунитета у медицинских работников г. Перми // Эпидемиология и вакцинопрофилактика. 2011. Т. 4, № 59. С. 45–48.
  8. Семененко Т.А., Готвянская Т.П., Кудрявцева Е.Н., Русакова Е.В., Ноздрачева А.В., Евсеева Л.Ф., Корабельникова М.И., Дубоделов Д.В., Шмыр И.С., Кузин С.Н. Частота обнаружения антител к вирусам кори, краснухи и эпидемического паротита у зарегистрированных в Московской области иностранных граждан (трудовых мигрантов) // Эпидемиология и вакцинопрофилактика. 2017. Т. 3, № 94. С. 11–15. doi: 10.31631/2073-3046-2017-16-3-11-15
  9. Сылка О.И., Харсеева Г.Г., Леонова И.А. Напряженность иммунитета к вирусу кори у населения г. Ростова-наДону // Журнал фундаментальной медицины и биологии. 2013. № 1. С. 41–43.
  10. Чеботарева И.В., Северская Н.В. Оценка напряженности иммунитета к кори у сотрудников медицинского центра // Клиническая лабораторная диагностика. 2016. № 9. С. 652.
  11. WHO. A monthly summary of the epidemiological data on selected Vaccine-preventable diseases in the WHO European Region. Reported measles cases for the period January–December 2018 (data as of 01 February 2019).
  12. WHO. 2018 Assessment report of the global vaccine action plan.

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Copyright (c) 2020 Sonis A.G., Gusyakova O.A., Gilmiyarova F.N., Ereshchenko A.A., Ignatova N.K., Kuzmicheva V.I., Borodina I.A., Nenjajkin S.S.

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