SUMMARY OF INFLUENZA AND OTHER RESPIRATORY VIRUSES DETECTED AND CHARACTERIZED IN RUSSIA DURING 2017–2018 SEASON

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Abstract

Abstract. The influenza season 2017–2018 started significantly later compared to the five previous seasons. Influenza epidemic lasted for 12 weeks (weeks 6–17), was of moderate intensity and 10,4% of the population of the country was involved with children aged 0–2 and 3–6 years being the most affected groups as usually. The average hospitalization rate of patients with ILI and ARI was 2,6% and was the highest in infants aged 0–2 years (5,4%). The number of influenzaassociated deaths was two times higher this season compared to 2016–2017 which can be attributed to the circulation of A(H1N1)pdm09 viruses that still is the major cause of lethal influenza outcomes in the country. A total 72 759 patients were investigated by RT-PCR in 55 collaborating RBLs. Laboratory confirmed influenza (LCI) was detected in 12 149 (20.7%) cases, of which 39.3% were influenza A(H1N1)pdm09 viruses, 29.6% were A(H3N2) and 31.1% influenza B (Yamagata lineage) viruses. The first cases of influenza viruses were detected at the very beginning of the season (weeks 40–45.2017), however a distinct increase in the rate of detection was registered only from the week 2.2018 with the peak on the week 13–14.2018 and subsequent gradual decline up to the end of the season. The certain differences in the etiology of morbidity between Federal Districts were registered. The impact of influenza and other ARI agents in different stage of epidemic was determined. In the pre-epidemic period, the incidence growth was occurred mainly due to ARI agents (about 32,7%), especially due to rhinoviruses (RhV) and RSV (10.2 and 8.0% cases, respectively) while LCI were registered in 3.4% only. During the epidemic, the rate of LCI detection increased up to 29.2% at simultaneous decrease in frequency of parainfluenza, adenovirus, bocavirus, coronavirus and, especially, rhinoviruses, to a lesser extent RSV infection. In the post-epidemic period, the role of influenza A(H1N1)pdm09, A(H3N2) and В viruses decreased up to 6.1; 6.9 and 3.6%, respectively, with increase of rhinoviruses (9.5% of diseases). Genetic analysis of influenza A(H1N1)pdm09 and A(H3N2) viruses circulating in 2017–2018 season showed that all analyzed viruses by the structure of surface genes encoding antigenic determinants, in difference from influenza B viruses, corresponded to the vaccine strains recommended by WHO for the Northern Hemisphere for 2017–2018 epidemic season. However, significant changes in the internal genes of circulating viruses were revealed. The control of the susceptibility of 316 influenza A and B viruses to antiviral drugs showed that the absolute majority of them (99.7%) retained their susceptibility to neuraminidase inhibitors.

About the authors

A. A. Sominina

Smorodintsev Research Institute of Influenza, St. Petersburg

Author for correspondence.
Email: anna.sominina@influenza.spb.ru

PhD, MD (Medicine), Professor, Honored Scientist of the Russian Federation, Head of the Laboratory of Risk Factors Assessment for Influenza and ARI

197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17
Phone: +7 (812) 499-15-29

Russian Federation

D. M. Danilenko

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Deputy Director on Science, Head of the Department of Etiology and Epidemiology of Influenza and ARVI Russian Federation

A. B. Komissarov

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Head of the Laboratory of Molecular Virology Russian Federation

A. V. Fadeev

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Researcher of the Laboratory of Molecular Virology Russian Federation

M. M. Pisareva

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Leading Researcher; Laboratory of Molecular Virology Russian Federation

M. Yu. Eropkin

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD, MD (Biology), Head of the Laboratory of Evolutionary Variability of Influenza Viruses Russian Federation

N. I. Konovalova

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Leading Researcher, Laboratory of Evolutionary Variability of Influenza Viruses Russian Federation

P. A. Petrova

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Junior Researcher, Laboratory of Evolutionary Variability of Influenza Viruses Russian Federation

A. A. Shtro

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Head of the Laboratory of Chemotherapy of Viral Infections Russian Federation

K. A. Stolyarov

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Leading Programmer, Laboratory of Epidemiology of Influenza and ARVI Russian Federation

L. S. Karpova

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Laboratory of Epidemiology of Influenza and ARVI Russian Federation

E. I. Burtseva

N.F. Gamaleya Federal Rerearch Center of Epidemiology and Microbiology, Moscow

Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Laboratory of Etiology and Epidemiology of Influenza and ARVI Russian Federation

A. V. Vasin

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Director;
Head of WHO National Influenza Centre

Russian Federation

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Copyright (c) 2018 Sominina A.A., Danilenko D.M., Komissarov A.B., Fadeev A.V., Pisareva M.M., Eropkin M.Y., Konovalova N.I., Petrova P.A., Shtro A.A., Stolyarov K.A., Karpova L.S., Burtseva E.I., Vasin A.V.

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