An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination

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Abstract

In theRussian Federation, Y. pestis NIIEG strain-based live attenuated vaccine is used for immunization against plaque on epidemiological indications, displaying high efficiency. However, individual fluctuations in adaptive immunity after vaccination necessitate conducting a search for genes underlying variability of developing immune response. Of note, HLA (Human Leukocyte Antigen) gene polymorphism plays an important role in this process. In our study, we identified HLA class II haplotypes for HLA-DRB1, HLA-DQA1, and HLA-DQB1 in 120 residents of theterritoryofPre-Caspiannatural plague focus, who were immunized against plague. In addition, level of TNFα production correlated with detecting allelic groups HLA-DRB1*04 (р = 0.05) and DRB1*12 (р = 0.01). The data obtained show that HLA class II gene polymorphism can affect the level of cytokine secretion in response to plague immunization. Examining the genes regulating immune factor production will allow to get better insight into the mechanisms underlying immune response variations after vaccination as well as contribute to predicting immunogenicity and efficiency of developing vaccine preparations. 

About the authors

O. M. Kudryavtseva

Russian Research Anti-Plague Institute «Microbe»

Author for correspondence.
Email: 3030774@mail.ru

PhD (Medicine), Senior Researcher, Department of Immunology

Contacts: Olga M. Kudryavtseva 410005, Russian Federation, Saratov, Universitetskaya str., 46, Russian Research Anti-Plague Institute “Microbe”. Phone: +7 (8452) 26-21-31 (office). Fax: +7 (452) 51-52-12.

Russian Federation

S. A. Bugorkova

Russian Research Anti-Plague Institute «Microbe»

Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Department of Immunology Russian Federation

T. N. Shchukovskaya

Russian Research Anti-Plague Institute «Microbe»

Email: fake@neicon.ru
PhD, MD (Medicine), Professor, Leading Researcher, Department of Immunology Russian Federation

N. I. Mikshis

Russian Research Anti-Plague Institute «Microbe»

Email: fake@neicon.ru
PhD, MD (Medicine), Leading Researcher, Department of Immunology Russian Federation

A. Yu. Goncharova

Russian Research Anti-Plague Institute «Microbe»

Email: fake@neicon.ru
PhD (Medicine), Researcher, Department of Immunology Russian Federation

S. N. Klyueva

Russian Research Anti-Plague Institute «Microbe»

Email: fake@neicon.ru
PhD (Biology), Researcher, Department of Immunology Russian Federation

S. A. Shcherbakova

Russian Research Anti-Plague Institute «Microbe»

Email: fake@neicon.ru
PhD, MD (Biology), Deputy Director for Scientific and Experimental Work Russian Federation

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Copyright (c) 2019 Kudryavtseva O.M., Bugorkova S.A., Shchukovskaya T.N., Mikshis N.I., Goncharova A.Y., Klyueva S.N., Shcherbakova S.A.

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