Characteristics of immune response in patients with acute chronic maxillary sinusitis associated with intra-cellular bacterial infections

Cover Page

Cite item

Abstract

Currently, chronic inflammatory pathology of paranasal sinuses mostly affecting maxillary antrum is one of the pressing issues for health care. Over the last two decades, a great etiological importance in inducing inflammation in paranasal sinuses was referred to bacterial intracellular infections caused by Mycoplasma and Chlamydia. In particular, Chlamydia, whose life cycle is closely linked to residence inside host cells defines them as pathogenic obligate intracellular gram-negative bacteria, whereas Mycoplasma is a membrane-associated microorganism able to self-replication and long persistence on host cellular membranes. Increased incidence of chronic pathology in paranasal sinuses associated with intracellular infection is shaped by a range of circumstances, primarily increased prevalence of immunocompromised subjects, worsened social and ecological conditions, uncontrolled and unjustified administration of available of antimicrobials and anti-septic agents, hormone preparations altering community of extracellular microbe populations (microbiocenoses), inhabiting natural biotope in the upper respiratory tract mucosa. These factors contribute to the lowering colony resistance, entrance and propagation of Chlamydia and Mycoplasma as a monoor mixed infection. Upon that, mixed variants of Chlamydia-Mycoplasma infection are characterized by development of more severe sinusitis accompanied with diverse complications in the lower respiratory tract, digestive tract, urinary and nerve system. There were examined 189 subjects for assessing epidemiologic characteristics and features of systemic and mucosal immune responses in patients with exacerbated chronic maxillary sinusitis associated with intracellular bacterial infection. Presence of intracellular bacterial infection was confirmed by laboratory tests: direct immune fluorescent analysis and PCR. It was found that high prevalence of Сhlamydia trachomatis, Chlamydophila pneumoniae and Mycoplasma pneumoniae in patients with exacerbated chronic inflammatory pathology of paranasal sinuses. Comparing laboratory test data for patients with identified intracellular bacterial pathogens vs. those with negative results revealed a common trend in pathologic immune-related changes that fits to typical host anti-infection response manifested by inflammatory process. Besides, we described features of immune reactivity in patients with verified Chlamydia infection including more pronounced unbalance in Т cell immunity as well as evelated parameters of humoral immunity in patients with verified Chlamydia and Mycoplasma infection.

About the authors

O. V. Parilova

Scientific Research Institute for Medical Problems of the North; State Khakassia N.F. Katanov’s University

Author for correspondence.
Email: olga-cet@yandex.ru
ORCID iD: 0000-0003-2948-9658

Olga V. Parilova, PhD (Medicine), Leading Researcher, Laboratory of Clinical Pathophysiology, Krasnoyarsk; Associate Professor, Department of General Professional Disciplines, Abakan

660022, Krasnoyarsk, Partizana Zheleznyaka str., 3G.

Phone: +7 (391) 212-52-88 (office); +7 913 034-37-80 (mobile).

Russian Federation

T. A. Kapustina

Scientific Research Institute for Medical Problems of the North

Email: tak34@yandex.ru

PhD, MD (Medicine), Head Researcher, Laboratory of Clinical Pathophysiology

Krasnoyarsk Russian Federation

A. N. Markina

Scientific Research Institute for Medical Problems of the North

Email: Angel.lor.ru@mail.ru

PhD (Medicine), Senior Researcher, Laboratory of Clinical Pathophysiology

Krasnoyarsk Russian Federation

E. V. Belova

Scientific Research Institute for Medical Problems of the North

Email: belova.ev@bk.ru

PhD (Medicine), Senior Researcher, Laboratory of Clinical Pathophysiology

Krasnoyarsk Russian Federation

References

  1. Белова Е.В., Капустина Т.А., Маркина А.Н., Парилова О.В Алгоритм лабораторной диагностики хламидийной инфекции у больных хроническим синуситом // Вестник оториноларингологии. 2015. Т. 80, № 4. С. 61–64. doi: 10.17116/otorino201580461-64.
  2. Борцов П.А., Федина Е.Д., Токарская Е.А., Мартынова В.Р., Зигангирова Н.А., Гинцбург А.Л. Регуляция хламидиями апоптоза клеток хозяина // Журнал микробиологии, эпидемиологии и иммунобиологии. 2006. № 4. С. 53–58.
  3. Капустина Т.А., Савченко А.А., Парилова О.В., Коленчукова О.А., Кин Т.И., Лопатникова Е.В. Иммунопатологические нарушения у больных с хроническим риносинуситом, сопряженным с хламидийной инфекцией // Якутский медицинский журнал. 2010. № 3 (31). С. 31–35.
  4. Козлов В.С., Савлевич Е.Л. Полипозный риносинусит. Современные подходы к изучению патогенеза, диагностике и лечению // Вестник оториноларингологии. 2015. № 4. С. 95–99. doi: 10.17116/otorino201580495-99
  5. Лиханова М.А., Бондарев О.И., Мингалев Н.В., Лебедева Р.Н. Полипозным риносинусит — вопросы этиопатогенеза // Омский научный вестник. 2014. № 2 (134). С. 56–59.
  6. Лобзин Ю.В., Сидорчук А.Л., Позняк С.Н. Клинико-лабораторная диагностика хламидия-индуцированных артропатий // Эпидемиология и инфекционные болезни. 2010. № 6. С. 48–51.
  7. Лопатин А.С., Иванченко О.А., Гаврилов П.П., Карпищенко С.А., Козлов Р.С., Кречикова О.И., Кухаренко О.А., Отвагин И.В., Сказатова О.И., Сопко О.Н., Пискунов Г.З. Микробный пейзаж верхнечелюстных пазух и среднего носового хода при хроническом риносинусите // Российская ринология. 2013. Т. 21, № 4. С. 4–8.
  8. Маянский А.Н. Микробиология и клинические проявления хламидиозов // Вопросы диагностики в педиатрии. 2012. Т. 4, № 5. С. 10–19.
  9. Михайлов Ю.Х. Некоторые теоретические и методологические проблемы современной ринологии // Военно-медицинский журнал 2006. № 6. С. 52–56.
  10. Пальчун В.Т., Гуров A.B., Руденко В.В. Хламидийная и микоплазменная инфекция в оториноларингологии (систематический обзор) // Вестник оториноларингологии. 2012. № 6. С. 91–97.
  11. Федорова В.А., Султанахмедов Э.С., Салтыков Ю.В., Утц С.Р., Мотин В.Л. Совершенствование лабораторной диагностики урогенитальной хламидийной инфекции у пациентов c нарушением репродуктивной функции, инфицированных Chlamydia trachomatis // Вестник дерматологии и венерологии. 2017. № 2. С. 34–44. doi: 10.25208/0042-4609-2017-0-2-34-44
  12. Хрянин А.А. Урогенитальная хламидийная инфекция у женщин: тактика ведения пациенток в соответствии с современными зарубежными и российскими рекомендациями // Вестник дерматологии и венерологии. 2015. № 2. С. 101–110. doi: 10.25208/0042-4609-2015-0-2-101-110.
  13. Fokkens W.J., Lund V.J., Mullol J., Bachert C., Alobid I., Baroody F., Cohen N., Cervin A., Douglas R., Gevaert P., Georgalas C., Goossens H., Harvey R., Hellings P., Hopkins C., Jones N., Joos G., Kalogjera L., Kern B., Kowalski M., Price D., Riechelmann H., Schlosser R., Senior B., Thomas M., Toskala E., Voegels R., de Wang Y., Wormald P.J. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinol. Suppl., 2012, vol. 50, no. 23, pp. 1–12. doi: 10.4193/Rhino50E2
  14. Javadi Nia S., Zarabi V., Noorbakhsh S., Farhadi M., Ghavidel Darestani S. Chlamydophila pneumoniae infection assessment in children with adenoid hypertrophy concomitant with rhino sinusitis. Jundishapur J. Microbiol., 2014, vol. 7, no. 8: e11134. doi: 10.5812/jjm.11134
  15. Principi N., Esposito S. Mycoplasma pneumoniae and Chlamydia pneumoniae cause lower respiratory tract disease in paediatric patients. Curr. Opin. Infect. Dis., 2002, vol. 15, no. 3, pp. 295–300.

Supplementary files

There are no supplementary files to display.


Copyright (c) 2019 Parilova O.V., Kapustina T.A., Markina A.N., Belova E.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies