ИСПОЛЬЗОВАНИЕ МЫШИНОЙ МОДЕЛИ ДЛЯ АНАЛИЗА ИММУННОГО ОТВЕТА К ИНФЕКЦИЯМ МЕТОДАМИ КЛАССИЧЕСКОЙ ГЕНЕТИКИ

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Резюме. Установление и изучение многочисленных функций всех генов человека является одной из главных задач современной биологической науки. Вследствие высокой степени гомологии между мышиным и человеческим геномами, важная роль в решении этой задачи принадлежит мышиной модели, использование которой в классической генетике особенно возросло в связи с выведением различных инбредных мышиных линий. Так, например, различия в иммунном ответе к инфекциям в разных мышиных линиях были неоднократно использованы для нахождения иммунологически компетентных генов. Именно поэтому трудно переоценить вклад мышиной модели в понимание механизмов иммунного ответа к инфекциям. В данном обзоре приведены некоторые из наиболее успешных и известных примеров использования мышей в изучении противоинфекционного ответа.

Об авторах

А. Полторак

Tufts University, Бостон

Автор, ответственный за переписку.
Email: alexander.poltorak@tufts.edu

Assistant Professor of Pathology, Graduate Program in Immunology, Graduate Program in Genetics

150 Harrison Avenue, J-512, Boston MA USA 02111

США

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