HPV-ASSOCIATED DISEASES IN THE STRUCTURE OF FEMALE REPRODUCTIVE TRACT TUMORS AND SEXUALLY TRANSMITTED INFECTIONS IN MOSCOW AND RUSSIA

Cover Page


Cite item

Full Text

Abstract

The group of female reproductive tract tumors includes cancers of corpus uteri, ovary, cervix, vulva and vagina (the last three are associated with HPV). Among the large group of sexually transmitted infections (STIs) there are only six infections, which subject to registration in the official statistical data in Russia: syphilis, gonorrhea, trichomoniasis, chlamydia, urogenital herpes and anogenital warts (AGWs). Occurrence of AGWs in 95–100% of cases caused by HPV types 6 and 11. Objectives: our aim was to determine the prevalence of HPV-associated diseases (cervical cancer and anogenital warts) in the structure of female reproductive tract tumors and STIs in recent years in Moscow, and to compare it with the prevalence in population of Russia. Methods: we analyzed retrospective data with diagnostic codes related to cancers of corpus uteri, ovary, cervix, vulva and vagina from the official statistic of cancer register using incidence and mortality rates between January 2007 and December 2015 in Russia and Moscow. We also analyzed retrospective data of STIs (incl. syphilis, gonorrhea, trichomoniasis, chlamydia, urogenital herpes and AGWs) incidence rates between January 2003 and December 2015. Results: average rate of cervical cancer incidence among the female reproductive tract tumors accounted for 23.7% in Moscow (29.8% in Russia). Average rate of cervical cancer mortality among the female reproductive tract tumors accounted for 24.1% in Moscow (28.3% in Russia). The rate of AGWs in the STIs structure (for both sexes) in Moscow increased from 11.5% in 2003 to 25.7% in 2015 (the maximum was 31.0% in 2014). The highest rate of AGWs was detected in the age group 15–17 years (up to 59.8% in 2012), followed by 18–29 years (up to 37.3% in 2014). The rate of AGWs was 11.7% among all STIs (in both sexes) in Russia in 2015. Conclusion: HPV-associated diseases (cervical cancer and AGWs) take up a significant place in the structure of female reproductive tract tumors and STIs. And in the structure of the STI for Moscow, AGWs moved from the 5th (in 2003) to the 1st (in 2015) ranked place, surpassing syphilis, gonorrhea, trichomoniasis and chlamydia. The effective prevention of HPV-infection would be able to improve the situation.

 

About the authors

N. I. Briko

Sechenov University, Moscow

Author for correspondence.
Email: nbrico@mail.ru
RAS Full Member, PhD, MD (Medicine), Professor, Head of the Department of Epidemiology and Evidence-based Medicine Russian Federation

P. D. Lopukhov

Sechenov University, Moscow

Email: nbrico@mail.ru
PhD Student, Department of Epidemiology and Evidence-based Medicine Russian Federation

A. D. Kaprin

P. Herzen Moscow Oncology Research Institute, Moscow

Email: nbrico@mail.ru
RAS Full Member, PhD, MD (Medicine), Professor, Director Russian Federation

E. G. Novikova

P. Herzen Moscow Oncology Research Institute, Moscow

Email: nbrico@mail.ru
PhD, MD (Medicine), Professor, Head of Gynaecologic Oncology Department Russian Federation

O. I. Trushina

P. Herzen Moscow Oncology Research Institute, Moscow

Email: nbrico@mail.ru
PhD, MD (Medicine), Senior Researcher, Gynaecologic Oncology Department Russian Federation

A. A. Khaldin

Moscow Research and Practical Center of Dermatology, Venereology and Cosmetology (MRPCDVC), Moscow

Email: nbrico@mail.ru
PhD, MD (Medicine), Professor, RANS Corresponding Member, Head Researcher Russian Federation

O. V. Zhukova

Moscow Research and Practical Center of Dermatology, Venereology and Cosmetology (MRPCDVC), Moscow

Email: nbrico@mail.ru
PhD, MD (Medicine), Chief Doctor Russian Federation

D. R. Isaeva

Moscow Research and Practical Center of Dermatology, Venereology and Cosmetology (MRPCDVC), Moscow

Email: nbrico@mail.ru
Dermatovenerologist Russian Federation

A. I. Skvortsova

Moscow Research and Practical Center of Dermatology, Venereology and Cosmetology (MRPCDVC), Moscow

Email: nbrico@mail.ru
Physician-methodologist of the Organizational and Methodical Cabinet on Dermatovenereology Russian Federation

References

  1. Злокачественные новообразования в России в 2007 году (заболеваемость и смертность). Под ред. Чиссова В.И., Старинского В.В., Петровой Г.В. М.: ФГУ «МНИОИ им. П.А. Герцена Росмедтехнологий», 2009. 244 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2007 godu (zabolevaemost’ i smertnost’). Pod red. Chissova V.I., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2007 (morbidity and mortality). Eds. Chissova V.I., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena Rosmedtekhnologii, 2009. 244 p.
  2. Злокачественные новообразования в России в 2008 году (заболеваемость и смертность). Под ред. Чиссова В.И., Старинского В.В., Петровой Г.В. М.: ФГУ «МНИОИ им. П.А. Герцена Росмедтехнологий», 2010. 256 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2008 godu (zabolevaemost’ i smertnost’). Pod red. Chissova V.I., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2008 (morbidity and mortality). Eds. Chissova V.I., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena Rosmedtekhnologii, 2010. 256 p.
  3. Злокачественные новообразования в России в 2009 году (заболеваемость и смертность). Под ред. Чиссова В.И., Старинского В.В., Петровой Г.В. М.: ФГУ «МНИОИ им. П.А. Герцена» Минздравсоцразвития России, 2011. 260 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2009 godu (zabolevaemost’ i smertnost’). Pod red. Chissova V.I., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2009 (morbidity and mortality). Eds. Chissova V.I., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena Minzdravsotsrazvitiya Rossii, 2011. 260 p.
  4. Злокачественные новообразования в России в 2010 году (заболеваемость и смертность). Под ред. Чиссова В.И., Старинского В.В., Петровой Г.В. М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздравсоцразвития России, 2012. 260 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2010 godu (zabolevaemost’ i smertnost’). Pod red. Chissova V.I., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2010 (morbidity and mortality). Eds. Chissova V.I., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena Minzdravsotsrazvitiya Rossii, 2012. 260 p.
  5. Злокачественные новообразования в России в 2011 году (заболеваемость и смертность). Под ред. Чиссова В.И., Старинского В.В., Петровой Г.В. М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России, 2013. 289 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2011 godu (zabolevaemost’ i smertnost’). Pod red. Chissova V.I., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2011 (morbidity and mortality). Eds. Chissova V.I., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena Minzdrava Rossii, 2013. 289 p.
  6. Злокачественные новообразования в России в 2012 году (заболеваемость и смертность). Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. М.: ФГБУ «МНИОИ им. П.А. Герцена» Минздрава России, 2014. 250 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2012 godu (zabolevaemost’ i smertnost’). Pod red. Kaprina A.D., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2012 (morbidity and mortality). Eds. Kaprina A.D., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena Minzdrava Rossii, 2014. 250 p.
  7. Злокачественные новообразования в России в 2013 году (заболеваемость и смертность). Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «ФМИЦ им. П.А. Герцена» Минздрава России, 2015. 250 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2013 godu (zabolevaemost’ i smertnost’). Pod red. Kaprina A.D., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2013 (morbidity and mortality). Eds. Kaprina A.D., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena – filial FGU «FMI im. P.A. Gercena» Minzdrava Rossii, 2015. 250 p.
  8. Злокачественные новообразования в России в 2014 году (заболеваемость и смертность). Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. М.: МНИОИ им. П.А. Герцена – филиал ФГУ «НМИРЦ» Минздрава России, 2016. 250 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2014 godu (zabolevaemost’ i smertnost’). Pod red. Kaprina A.D., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2014 (morbidity and mortality). Eds. Kaprina A.D., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena filial FGU «NMIRTs» Minzdrava Rossii, 2016. 250 p.
  9. Злокачественные новообразования в России в 2015 году (заболеваемость и смертность). Под ред. Каприна А.Д., Старинского В.В., Петровой Г.В. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России, 2017. 250 с. [Zlokachestvennye novoobrazovaniya v Rossii v 2015 godu (zabolevaemost’ i smertnost’). Pod red. Kaprina A.D., Starinskogo V.V., Petrovoi G.V. [Malignancies in Russia in 2015 (morbidity and mortality). Eds. Kaprina A.D., Starinskogo V.V., Petrovoi G.V.]. Moscow: Moskovskiy nauchno-issledovatel’skiy onkologicheskiy institut im. P.A. Gertsena – filial FGU «NMIRTs » Minzdrava Rossii, 2017. 250 p.
  10. Bosch F.X., Broker T.R., Forman D., Moscicki A.B., Gillison M.L., Doorbar J., Stern P.L., Stanley M., Arbyn M., Poljak M., Cuzick J., Castle P.E., Schiller J.T., Markowitz L.E., Fisher W.A., Canfell K., Denny L.A., Franco E.L., Steben M., Kane M.A., Schiffman M., Meijer C.J., Sankaranarayanan R., Castellsagué X., Kim J.J., Brotons M., Alemany L., Albero G., Diaz M., de Sanjosé S. Comprehensive control of human papillomavirus infections and related diseases. Vaccine, 2013, vol. 31, suppl. 7, pp. H1–H31. doi: 10.1016/j.vaccine.2013.10.003
  11. Cubie H.A. Diseases associated with human papillomavirus infection. Virology, 2013, vol. 445, iss. 1–2, pp. 21–34. doi: 10.1016/j. virol.2013.06.007
  12. De Vuyst H., Clifford G.M., Nascimento M.C., Madeleine M.M., Franceschi S. Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: a meta-analysis. Int. J. Cancer, 2009, vol. 124, iss. 7, pp. 1626–1636. doi: 10.1002/ijc.24116
  13. Forman D., de Martel C., Lacey C.J., Soerjomataram I., Lortet-Tieulent J., Bruni L., Vignat J., Ferlay J., Bray F., Plummer M., Franceschi S. Global burden of human papillomavirus and related diseases. Vaccine, 2012, vol. 30, suppl. 5, pp. F12–F23. doi: 10.1016/j.vaccine.2012.07.055
  14. Li N., Franceschi S., Howell-Jones R., Snijders P.J., Clifford G.M. Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: variation by geographical region, histological type and year of publication. Int. J. Cancer, 2011, vol. 128, iss. 4, pp. 927–935. doi: 10.1002/ijc.25396
  15. Schiffman M.H., Bauer H.M., Hoover R.N., Hoover R.N., Glass A.G., Cadell D.M., Rush B.B., Scott D.R., Sherman M.E., Kurman R.J., Wacholder S., Stanton C.K., Manos M.M. Epidemiologic evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J. Nat. Cancer Inst., 1993, vol. 85, iss. 12, pp. 958–964. doi: 10.1093/jnci/85.12.958
  16. Zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat. Rev. Cancer, 2002, no. 2, pp. 342–350. doi: 10.1038/nrc798
  17. Zur Hausen H. Papillomavirus in the causation of human cancers — a brief historical account. Virology, 2009, vol. 384, iss. 2, pp. 260–265. doi: 10.1016/j.virol.2008.11.046
  18. Zur Hausen H. The search for infectious causes of human cancers: where and why. Virology, 2009, vol. 392, iss. 1, pp. 1–10. doi: 10.1016/j.virol.2009.06.001
  19. World Health Organization. World Cancer Report 2014. Eds. Stewart B.W., Wild C.P. 2014, 630 p. URL: http://publications.iarc.fr/ Non-Series-Publications/World-Cancer-Reports/World-Cancer-Report-2014 (29.12.2017)

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2018 Briko N.I., Lopukhov P.D., Kaprin A.D., Novikova E.G., Trushina O.I., Khaldin A.A., Zhukova O.V., Isaeva D.R., Skvortsova A.I.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 64788 от 02.02.2016.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies