SUMMARY OF INFLUENZA AND OTHER RESPIRATORY VIRUSES DETECTED AND CHARACTERIZED IN RUSSIA DURING 2017–2018 SEASON

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Abstract

Abstract. The influenza season 2017–2018 started significantly later compared to the five previous seasons. Influenza epidemic lasted for 12 weeks (weeks 6–17), was of moderate intensity and 10,4% of the population of the country was involved with children aged 0–2 and 3–6 years being the most affected groups as usually. The average hospitalization rate of patients with ILI and ARI was 2,6% and was the highest in infants aged 0–2 years (5,4%). The number of influenzaassociated deaths was two times higher this season compared to 2016–2017 which can be attributed to the circulation of A(H1N1)pdm09 viruses that still is the major cause of lethal influenza outcomes in the country. A total 72 759 patients were investigated by RT-PCR in 55 collaborating RBLs. Laboratory confirmed influenza (LCI) was detected in 12 149 (20.7%) cases, of which 39.3% were influenza A(H1N1)pdm09 viruses, 29.6% were A(H3N2) and 31.1% influenza B (Yamagata lineage) viruses. The first cases of influenza viruses were detected at the very beginning of the season (weeks 40–45.2017), however a distinct increase in the rate of detection was registered only from the week 2.2018 with the peak on the week 13–14.2018 and subsequent gradual decline up to the end of the season. The certain differences in the etiology of morbidity between Federal Districts were registered. The impact of influenza and other ARI agents in different stage of epidemic was determined. In the pre-epidemic period, the incidence growth was occurred mainly due to ARI agents (about 32,7%), especially due to rhinoviruses (RhV) and RSV (10.2 and 8.0% cases, respectively) while LCI were registered in 3.4% only. During the epidemic, the rate of LCI detection increased up to 29.2% at simultaneous decrease in frequency of parainfluenza, adenovirus, bocavirus, coronavirus and, especially, rhinoviruses, to a lesser extent RSV infection. In the post-epidemic period, the role of influenza A(H1N1)pdm09, A(H3N2) and В viruses decreased up to 6.1; 6.9 and 3.6%, respectively, with increase of rhinoviruses (9.5% of diseases). Genetic analysis of influenza A(H1N1)pdm09 and A(H3N2) viruses circulating in 2017–2018 season showed that all analyzed viruses by the structure of surface genes encoding antigenic determinants, in difference from influenza B viruses, corresponded to the vaccine strains recommended by WHO for the Northern Hemisphere for 2017–2018 epidemic season. However, significant changes in the internal genes of circulating viruses were revealed. The control of the susceptibility of 316 influenza A and B viruses to antiviral drugs showed that the absolute majority of them (99.7%) retained their susceptibility to neuraminidase inhibitors.

About the authors

A. A. Sominina

Smorodintsev Research Institute of Influenza, St. Petersburg

Author for correspondence.
Email: anna.sominina@influenza.spb.ru

PhD, MD (Medicine), Professor, Honored Scientist of the Russian Federation, Head of the Laboratory of Risk Factors Assessment for Influenza and ARI

197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17
Phone: +7 (812) 499-15-29

Russian Federation

D. M. Danilenko

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Deputy Director on Science, Head of the Department of Etiology and Epidemiology of Influenza and ARVI Russian Federation

A. B. Komissarov

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Head of the Laboratory of Molecular Virology Russian Federation

A. V. Fadeev

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Researcher of the Laboratory of Molecular Virology Russian Federation

M. M. Pisareva

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Leading Researcher; Laboratory of Molecular Virology Russian Federation

M. Yu. Eropkin

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD, MD (Biology), Head of the Laboratory of Evolutionary Variability of Influenza Viruses Russian Federation

N. I. Konovalova

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Leading Researcher, Laboratory of Evolutionary Variability of Influenza Viruses Russian Federation

P. A. Petrova

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Junior Researcher, Laboratory of Evolutionary Variability of Influenza Viruses Russian Federation

A. A. Shtro

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Head of the Laboratory of Chemotherapy of Viral Infections Russian Federation

K. A. Stolyarov

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
Leading Programmer, Laboratory of Epidemiology of Influenza and ARVI Russian Federation

L. S. Karpova

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Laboratory of Epidemiology of Influenza and ARVI Russian Federation

E. I. Burtseva

N.F. Gamaleya Federal Rerearch Center of Epidemiology and Microbiology, Moscow

Email: fake@neicon.ru
PhD, MD (Medicine), Head of the Laboratory of Etiology and Epidemiology of Influenza and ARVI Russian Federation

A. V. Vasin

Smorodintsev Research Institute of Influenza, St. Petersburg

Email: fake@neicon.ru
PhD (Biology), Director;
Head of WHO National Influenza Centre

Russian Federation

References

  1. Карпова Л.С., Волик К.М., Столяров К.А., Поповцева Н.М., Столярова Т.П., Соминина А.А., Бурцева Е.И. Особенности эпидемического процесса при гриппе A(H1N1)pdm09 и A(H3N2) в России с 2009 по 2017 годы // Вопросы вирусологии. 2018. Т. 63, № 4. С. 177–184. [Karpova L.S., Volik K.M., Stolyarov K.A., Popovtseva N.M., Stolyarova T.P., Sominina A.A., Burtseva E.I. Features of the epidemic process for influenza A (H1N1) pdm09 and A (H3N2) in Russia from 2009 to 2017. Voprosy Virusologii = Problems of Virology, 2018, vol. 63, no. 4, pp. 177–184. doi: 10.31631/2073-3046-2018-17-1-13-19 (In Russ.)]
  2. Методика расчета эпидемических порогов по гриппу и острым респираторным вирусным инфекциям по субъектам Российской Федерации: метод. рекомендации МР 3.1.0005-10. М., 2010. 86 c. [The method of calculation of the epidemic threshold for influenza and acute respiratory viral infections by the subjects of the Russian Federation: methodological recommendations МR 3.1.0005-10. Moscow: 2010. 86 p.]. URL: http://www.rospotrebnadzor.ru/documents/details.php?ELEMENT_ID=6288 (20.09.2018)
  3. Выделение вирусов гриппа в клеточных культурах и куриных эмбрионах и их идентификация: метод. рекомендации № 0100/4430-06-34 (утв. Федеральной службой по надзору в сфере защиты прав потребителей и благополучия человека от 18 апреля 2006 г.). 15 c. [Isolation of seasonal and potentially pandemic influenza viruses in cell cultures and chick embryos and their identification: methodological recommendations No. 0100/ 4430-06-34. (approved by Federal Service for Supervision of Consumer Rights Protection and Human Welfare of April 18, 2006). 15 p.]
  4. Михайлова Е.В., Чудакова Т.К., Ярушкина М.С., Романовская А.В., Хворостухина Н.Ф. Респираторно-синцитиальная вирусная инфекция: клинические особенности и лабораторные показатели интоксикации // Детские инфекции. 2017. Т. 16, № 2. С. 23–25. [Mikhailova E.V., Chudakova T.K., Yarushkina M.S., Romanovskaya A.V., Khvorostukhina N.F. Respiratory syncytial viral infection: clinical features and laboratory indicators of intoxication. Detskie infektsii = Children’s infections, 2017, vol. 16, no. 2, pp. 23–25. (In Russ.)]
  5. Соминина А.А., Смородинцева Е.А., Столяров К.А., Мельникова А.А. Совершенствование системы надзора за гриппом в Российской Федерации: основные результаты сигнального надзора за гриппом и другими острыми респираторными вирусными инфекциями // Эпидемиология и вакцинопрофилактика. 2017. Т. 16, № 1. С. 7–15. [Sominina A.A., Smorodintseva E.A., Stolyarov K.A., Melnikova A.A. Improving the system of influenza surveillance in the Russian Federation: the main results of sentinel surveillance for influenza and other acute respiratory viral infections. Epidemiologiya i vaktsinoprofilaktika = Epidemiology and Vaccine Prevention, 2017, vol. 16, no. 1, pp. 7–15. doi: 10.31631/2073-3046-2017-16-1-7-15 (In Russ.)]
  6. Ilyicheva T., Durymanov A., Susloparov I, Kolosova N., Goncharova N., Svyatchenko S., Petrova O., Bondar A., Mikheev V., Ryzhikov A. Fatal cases of seasonal influenza in Russia in 2015–2016. PLoS ONE, 2016, vol. 11, no. 10: e0165332.
  7. Komissarov A., Fadeev A., Sergeeva M., Petrov S., Sintsova K., Egorova A., Pisareva M., Buzitskaya Z., Musaeva T., Danilenko D., Konovalova N., Petrova P., Stolyarov K., Smorodintseva E., Burtseva E., Krasnoslobodtsev K., Kirillova E., Karpova L., Eropkin M., Sominina A., Grudinin M. Rapid spread of influenza A(H1N1)pdm09 viruses with a new set of specific mutations in the internal genes in the beginning of 2015/2016 epidemic season in Moscow and Saint Petersburg (Russian Federation). Influenza Other Respir. Viruses, 2016, vol. 4, pp. 247–253. doi: 10.1111/irv.12389
  8. Lozano R., Naghavi M., Foreman K., Lim S., Shibuya K., Aboyans V., Abraham J., Adair T., Aggarwal R., Ahn S.Y., Alvarado M., Anderson H.R., Anderson L.M., Andrews K.G., Atkinson C., Baddour L.M., Barker-Collo S., Bartels D.H., Bell M.L., Benjamin E.J., Bennett D., Bhalla K., Bikbov B., Bin Abdulhak A., Birbeck G., Blyth F., Bolliger I., Boufous S., Bucello C., Burch M., Burney P., Carapetis J., Chen H., Chou D., Chugh S.S., Coffeng L.E., Colan S.D., Colquhoun S., Colson K.E., Condon J., Connor M.D., Cooper L.T., Corriere M., Cortinovis M., de Vaccaro K.C., Couser W., Cowie B.C., Criqui M.H., Cross M., Dabhadkar K.C., Dahodwala N., De Leo D., Degenhardt L., Delossantos A., Denenberg J., Des Jarlais D.C., Dharmaratne S.D., Dorsey E.R., Driscoll T., Duber H., Ebel B., Erwin P.J., Espindola P., Ezzati M., Feigin V., Flaxman A.D., Forouzanfar M.H., Fowkes F.G., Franklin R., Fransen M., Freeman M.K., Gabriel S.E., Gakidou E., Gaspari F., Gillum R.F., Gonzalez-Medina D., Halasa Y.A., Haring D., Harrison J.E., Havmoeller R., Hay R.J., Hoen B., Hotez P.J., Hoy D., Jacobsen K.H., James S.L., Jasrasaria R., Jayaraman S., Johns N., Karthikeyan G., Kassebaum N., Keren A., Khoo J.P., Knowlton L.M., Kobusingye O., Koranteng A., Krishnamurthi R., Lipnick M., Lipshultz S.E., Ohno S.L., Mabweijano J., MacIntyre M.F., Mallinger L., March L., Marks G.B., Marks R., Matsumori A., Matzopoulos R., Mayosi B.M., McAnulty J.H., McDermott M.M., McGrath J., Mensah G.A., Merriman T.R., Michaud C., Miller M., Miller T.R., Mock C., Mocumbi A.O., Mokdad A.A., Moran A., Mulholland K., Nair M.N., Naldi L., Narayan K.M., Nasseri K., Norman P., O’Donnell M., Omer S.B., Ortblad K., Osborne R., Ozgediz D., Pahari B., Pandian J.D., Rivero A.P., Padilla R.P., PerezRuiz F., Perico N., Phillips D., Pierce K., Pope C.A. 3rd, Porrini E., Pourmalek F., Raju M., Ranganathan D., Rehm J.T., Rein D.B., Remuzzi G., Rivara F.P., Roberts T., De León F.R., Rosenfeld L.C., Rushton L., Sacco R.L., Salomon J.A., Sampson U., Sanman E., Schwebel D.C., Segui-Gomez M., Shepard D.S., Singh D., Singleton J., Sliwa K., Smith E., Steer A., Taylor J.A., Thomas B., Tleyjeh I.M., Towbin J.A., Truelsen T., Undurraga E.A., Venketasubramanian N., Vijayakumar L., Vos T., Wagner G.R., Wang M., Wang W., Watt K., Weinstock M.A., Weintraub R., Wilkinson J.D., Woolf A.D., Wulf S., Yeh P.H., Yip P., Zabetian A., Zheng Z.J., Lopez A.D., Murray C.J., AlMazroa M.A., Memish Z.A. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet, 2012, vol. 380, no. 9859, pp. 2095–2128. doi: 10.1016/S0140-6736(12)61728-0
  9. Lopez-Labrador Х., Natividad-Sancho A., Pisareva M., Komissarov A., Salvatierra K., Fadeev A., Moya A., Grudinin M., DiezDomingo J., Afanasieva O., Konovalova N., Sominina A., Puig-Barbera J. Genetic characterization of influenza viruses from influenza-related hospital admissions in the St. Petersburg and Valencia sites of the Global Influenza Hospital Surveillance Network during the 2013/14 influenza season. J. Clin. Virol., 2016, vol. 84, pp. 32–38.
  10. Manual for the laboratory diagnosis and virological surveillance of influenza. WHO, 2011. 139 p.
  11. Moe N., Stenseng I.H., Krokstad S., Christensen A., Skanke L.H., Risnes K.R., Nordbø S.A., Døllner H. The burden of human metapneumovirus and respiratory syncytial virus infections in hospitalized norwegian children. J. Infect. Dis., 2017, vol. 216, no. 1, pp. 110–116.
  12. Morbidity and Mortality Weekly Report. Influenza activity in the United States during the 2017–18 season and composition of the 2018–19 influenza vaccine. MMWR, 2018, vol. 67, no. 22, pp. 634–642.
  13. Nair H., Brooks W.A., Katz M., Roca A., Berkley J.A., Madhi S.A., Simmerman J.M., Gordon A., Sato M., Howie S., Krishnan A., Ope M., Lindblade K.A., Carosone-Link P., Lucero M., Ochieng W., Kamimoto L., Dueger E., Bhat N., Vong S., Theodoratou E., Chittaganpitch M., Chimah O., Balmaseda A., Buchy P., Harris E., Evans V., Katayose M., Gaur B., O’CallaghanGordo C., Goswami D., Arvelo W., Venter M., Briese T., Tokarz R., Widdowson M.A., Mounts A.W., Breiman R.F., Feikin D.R., Klugman K.P., Olsen S.J., Gessner B.D., Wright P.F., Rudan I., Broor S., Simões E.A., Campbell H. Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis. Lancet, 2011, vol. 378, no. 9807, pp. 1917–1930. doi: 10.1016/S0140-6736(11)61051-9
  14. Puig-Barberà J., Tormos A., Trushakova S., Burtseva E., Sominina A., Pisareva M., Ciblak M.A., Badur S., Yu H., Cowling B.J., Burtseva E. The Global Influenza Hospital Surveillance Network (GIHSN): a new platform to describe the epidemiology of severe influenza. Influenza Other Respir. Viruses, 2015, vol. 9, no. 6, pp. 277–286. doi: 10.1111/irv.12335
  15. Ray R., Dos Santos G., O Buck P., Claeys C., Matias G., Innis B., Bekkat-Berkani R.. A review of the value of quadrivalent influenza vaccines and their potential contribution to influenza control. Human Vaccines & Immunotherapeutics, 2017, vol. 13, no. 7, pp. 1640–1652. doi: 10.1080/21645515.2017.1313375
  16. Ruggiero T., De Rosa F., Cerutti F., Pagani N., Allice T., Stella M., Milia M.G., Calcagno A., Burdino E., Gregori G., Urbino R., Di Perri G., Ranieri M.V., Ghisetti V. A(H1N1)pdm09 hemagglutinin D222G and D222N variants are frequently harbored by patients requiring extracorporeal membrane oxygenation and advanced respiratory assistance for severe A(H1N1)pdm09 infection. Influenza Other Respir. Viruses, 2013, vol. 7, no. 6, pp. 1416–1426.
  17. Shi T., McAllister D.A., O’Brien K.L., Simoes E.A.F., Madhi S.A., Gessner B.D., Polack F.P., Balsells E., Acacio S., Aguayo C., Alassani I., Ali A., Antonio M., Awasthi S., Awori J.O., Azziz-Baumgartner E., Baggett H.C., Baillie V.L., Balmaseda A., Barahona A., Basnet S., Bassat Q., Basualdo W., Bigogo G., Bont L., Breiman R.F., Brooks W.A., Broor S., Bruce N., Bruden D., Buchy P., Campbell S., Carosone-Link P., Chadha M., Chipeta J., Chou M., Clara W., Cohen C., de Cuellar E., Dang D.A., Dash-yandag B., Deloria-Knoll M., Dherani M., Eap T., Ebruke B.E., Echavarria M., de Freitas Lázaro Emediato C.C., Fasce R.A., Feikin D.R., Feng L., Gentile A., Gordon A., Goswami D., Goyet S., Groome M., Halasa N., Hirve S., Homaira N., Howie S.R.C., Jara J., Jroundi I., Kartasasmita C.B., Khuri-Bulos N., Kotloff K.L., Krishnan A., Libster R., Lopez O., Lucero M.G., Lucion F., Lupisan S.P., Marcone D.N., McCracken J.P., Mejia M., Moisi J.C., Montgomery J.M., Moore D.P., Moraleda C., Moyes J., Munywoki P., Mutyara K., Nicol M.P., Nokes D.J., Nymadawa P., da Costa Oliveira M.T., Oshitani H., Pandey N., Paranhos-Baccalà G., Phillips L.N., Picot V.S., Rahman M., Rakoto-Andrianarivelo M., Rasmussen Z.A., Rath B.A., Robinson A., Romero C., Russomando G., Salimi V., Sawatwong P., Scheltema N., Schweiger B., Scott J.A.G., Seidenberg P., Shen K., Singleton R., Sotomayor V., Strand T.A., Sutanto A., Sylla M., Tapia M.D., Thamthitiwat S., Thomas E.D., Tokarz R., Turner C., Venter M., Waicharoen S., Wang J., Watthanaworawit W., Yoshida L.-M., Yu H., Zar H.J., Campbell H., Nair H., RSV Global Epidemiology Network. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet, 2017, vol. 390, no. 10098, pp. 946–958. doi: 10.1016/S0140-6736(17)30938-8
  18. Sominina A., Burtseva E., Eropkin M., Karpova L., Zarubaev V., Smorodintseva E., Konovalova N., Danilenko D., Prokopetz A., Grudinin M., Pisareva M., Anfimov P., Stolyarov K., Kiselev O., Shevchenko E., Ivanova V., Trushakova S., Breslav N., Lvov D., Klimov A., Moen A., Cox N. Influenza surveillance in Russia based on epidemiological and laboratory data for the period from 2005 to 2012. Am. J. Infect. Dis., 2013, vol. 9, no. 3, pp. 77–93. doi: 10.3844/ajidsp.2013.77.93
  19. Sominina A.A., Pisareva M.M., Grudinin M.P., Eropkin M.Y., Konovalova N.I., Sukhovetskaya V.F., Afanasieva O.I., Voloshuk L.V., Komissarov A.B., Buzitskaya Z.V., Fadeev A.V., Stolyarov K.A., Smorodintseva E.A., Afanasieva V.S., Yanina M.A., Gonchar V.V., Osidak L.V., Go A.A. Two years of experience in hospital surveillance for the severe influenza like illnesses in St. Petersburg: etiology, clinical characterization of diseases, antigenic and genetic properties of isolated influenza viruses. Microbiol. Mol. Biol. Rev, 2015, vol. 2, no. 1, pp. 44–55. doi: 10.18527/2500-2236-2015-2-1-44-55
  20. Vega T., Lozano J., Meerhoff T., Snaken R., Mott J., Ortiz de Lejarazu, Nunes B. Influenza surveillance in Europe: establishing epidemic thresholds by the moving epidemic method. Influenza Other Respir. Viruses, 2013, vol. 7, no. 4, pp. 546–558. doi: 10.1111/j.1750-2659.2012.00422x
  21. World Health Organization. Vaccines against influenza WHO position paper — November 2012. Wkly Epidemiol. Rec., 2012, vol. 87 (47), pp. 461–476.
  22. Zheng X.Y., Xu Y.J., Guan W.J., Lin L.F. Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review. Arch. Virol., 2018, vol. 163, no. 4, pp. 845–853.

Copyright (c) 2018 Sominina A.A., Danilenko D.M., Komissarov A.B., Fadeev A.V., Pisareva M.M., Eropkin M.Y., Konovalova N.I., Petrova P.A., Shtro A.A., Stolyarov K.A., Karpova L.S., Burtseva E.I., Vasin A.V.

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