THE CLINICAL AND LABORATORY EFFECTIVENESS OF OSELTAMIVIR FOR TREATMENT OF INFLUENZA IN HOSPITALIZED PATIENTS

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Abstract

The goal of our study was to estimate the efficacy of antiviral drug Oseltamivir for influenza treatment. We assessed the effect of Oseltamivir on the immune status of the 75 patients. It was formed 2 groups of observations with confirmed diagnosis of influenza: 38 received therapy Oseltamivir and 37 people receiving pathogenetic treatment. Treatment Oseltamivir contributes to a significant reduction in the duration of the catarrhal and intoxication syndromes and prevents the development of complications and exacerbations of chronic disease in persons with modified backdrop premorbid, which indicates for its high antiviral activity. We can assume the effect of Oseltamivir for restore the disturbed balance of cytokines, on assessing the dynamics of IL-1β, IL-8, IFNα, IFNγ in the serum.

About the authors

L. V. Voloschcuk

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Author for correspondence.
Email: 7970747@mail.ru
PhD (Medicine), Senior Researcher, Division of Viral Respiratory Infections in Adults, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

E. G. Golovacheva

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru
PhD (Medicine), Senior Researcher, Division of Viral Respiratory Infections in Children, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

A. A. Go

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru
Chief, Division of Viral Respiratory Infections in Adults, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

A. L. Mushkatina

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru
Researcher, Division of Viral Respiratory Infections in Adults, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

P. V. Zarishnuk

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru
Senior Researcher, Division of Viral Respiratory Infections in Adults, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

G. L. Dnieprovskay

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru
Leading Researcher Division of Viral Respiratory Infections in Adults Ministry of Health Development of the Russian Federation Research Institute of Influenza, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

T. L. Tumina

Research Institute of Influenza Ministry of Healthcare of the Russian Federation

Email: fake@neicon.ru
Researcher, Division of Viral Respiratory Infections in Adults, 197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17 Russian Federation

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Copyright (c) 2015 Voloschcuk L.V., Golovacheva E.G., Go A.A., Mushkatina A.L., Zarishnuk P.V., Dnieprovskay G.L., Tumina T.L.

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