Correlation of LP-PLA2 levels and the monocyte on population in the risk of atherosclerosis


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Abstract

Cardiovascular Disease (CVD) is the most significant cause of death worldwide. More than 17.9 million people died from CVD of which 85% of them were dead due to heart diseases such as heart attack and stroke. On the other hand, atherosclerosis is one of the most dominant CVD in most developing countries and developed countries.Lp-PLA2 is an enzyme produced by inflammatory cells and pro-atherogenic protein in atherosclerosis. In the process, monocytes will produce Lp-PLA2. Lp-PLA2 will hydrolyze oxLDL into lysophosphatidylcholine (lysoPC) and oxidized fatty acids (oxFA), which are atherogenic protein that involved in the atherogenesis. A chronicle inflammatory process occurs at different stages of atherosclerosis, and the stages of atherosclerosis development are essential stages that require early detection to avoid CVD severity. The research aims to determine the correlation of Lp-PLA2 concentration with monocyte numbers and percentages in populations with conditions at risk of atherosclerosis. This study was descriptive correlational analytic on the population with conditions at risk of atherosclerosis. The total number of respondents sampled in this research was 86 respondents. ELISA method was used to measure Lp-PLA2 concentration, and the Hematology Analyzer method was used to measure the number and percentage of monocyte. Based on One Way ANOVA test, the significance (p<0.05) portray by gender, age, body mass index (BMI), blood pressure, fasting blood sugar and lipid profile for monocyte meanwhile, in Lp-PLA2, only gender, age, body mass index (BMI), blood pressure and fasting sugar blood show significance (p<0.05).  Based on the Spearman Correlation Analysis, the relationship between monocytes and LP-PLA2 produces a probability value of 0.028. The correlation coefficient of 0.789 is categorised as very strong. This research concludes that an increase in the concentration of Lp-PLA2 correlates with an increase in the number and percentage of monocyte in a population with conditions at risk of atherosclerosis.

About the authors

Kumboyono Kumboyono

Faculty of Health Sciences, University of Brawijaya, 65145, Indonesia

Email: publikasikoe@gmail.com
ORCID iD: 0000-0003-2124-8673
Indonesia

Indah Nur Chomsy

Doctoral Program of Medical Science, Faculty of Medicine, University of Brawijaya, Malang, 65145, Indonesia

Email: indahncys@gmail.com
ORCID iD: 0000-0002-1050-3571
Indonesia

Dinesh Vijayadas

Email: vidst@icloud.com

Titin Andri Wihastuti

Author for correspondence.
Email: titinwihastuti@gmail.com
ORCID iD: 0000-0001-6476-0541

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Copyright (c) Kumboyono K., Chomsy I.N., Vijayadas D., Wihastuti T.A.

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