ESTIMATION OF ALLERGIC SENSITIZATION TO SOME MOLD FUNGI ACCORDING TO THE DATA OF THE CLINICAL AND DIAGNOSTIC CENTER OF THE G.N. GABRICHEVSKY SCIENTIFIC RESEARH INSTITUTE FOR EPIDEMIOLOGY AND MICROBIOLOGY


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Abstract. The assessment of allergic sensitization of 894 patients (478 of them – in 2018 and 416 – in 2019) who were examined at the consultative and Diagnostic center of G.N. Gabrichevsky Scientific Research Institute for Epidemiology and Microbiology, Moscow, for Certain mold fungi was carried out by determining specific IgE antibodies in blood serum by a highly specific and highly sensitive immunoblot method (RIDA AllergyScreen test systems, R-Biopharm AG, Germany). The prevalence of patients with elevated levels of specific IgE antibodies to mold fungi Alternaria alternata, Aspergillus fumigatus, Cladosporium herbarum and Penicillium notatum was established. All the examined patients in each year were divided into two age groups: 1 – a group of children aged 1 to 17 years, 548 children in just two years (303 of them girls and 245 boys), 2 – a group of adults aged 18 years and older, 346 people in just two years (231 of them women and 115 men). Results. In 2018, out of 478 serum samples, atopic sensitization to mold fungi was detected in 25.3% (n=121) of the examined, of which 17.9% (n=86) in group 1, and 2 – 7.4% (n=35). In 2019, out of 416 serum samples, atopic sensitization to mold fungi was detected in 20.7% (n=86) of the examined, of which 13.5% (n=56) in group 1, and 2 – 7.2% (n=30). In 2018, out of 121 positive samples, specific IgE antibodies to various mold fungi were slightly more often detected in females – 53.7% (n=65), of which 75.3% (n=49) were girls, 24.7% (n=16) were women. In 2019, out of 86 positive samples, specific IgE antibodies to various mold fungi were slightly more often detected in males – 51.2% (n=44), of which 79.5% (n=35) were boys, and 20.5% (n=9) were men. Atopic sensitization to the mold fungus Alternaria alternata was most often detected: during the period under review, out of 207 positive samples, it was determined in 186 samples (89.9%). IgE antibodies in the blood serum to mold fungi are more often detected in children under the age of 17, regardless of the patient's gender.

About the authors

V. А. Metelskaya

G.N. Gabrichevsky Scientific Research Institute for Epidemiology and Microbiology
125212, Russia, Moscow, Admiral Makarov str., 10

Email: pevek.1972@mail.ru

Academic degree - Candidate of Biological Sciences, position - senior researcher

Russian Federation

N. S. Matveevskaya

G.N. Gabrichevsky Scientific Research Institute for Epidemiology and Microbiology
125212, Russia, Moscow, Admiral Makarov str., 10

Email: matveevskaya@mail.ru
ORCID iD: 0000-0002-8854-4760

Academic degree - Candidate of Biological Sciences, academic title - senior researcher, position - leading researcher.

Russian Federation

O. G. Grechishnikova

G.N. Gabrichevsky Scientific Research Institute for Epidemiology and Microbiology
125212, Russia, Moscow, Admiral Makarov str., 10

Email: grecha77@mail.ru

Academic degree - Candidate of Biological Sciences, position - senior researcher.

Russian Federation

A. V. Safronova

G.N. Gabrichevsky Scientific Research Institute for Epidemiology and Microbiology
125212, Russia, Moscow, Admiral Makarov str., 10

Author for correspondence.
Email: 4520732@mail.ru

Academic degree - Candidate of Medical Sciences, position - leading researcher.

Russian Federation

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Copyright (c) Metelskaya V.А., Matveevskaya N.S., Grechishnikova O.G., Safronova A.V.

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