COMPARISON OF VITAMIN D LEVELS BETWEEN MOTHERS AND INFANTS WITH AND WITHOUT PROLONGED RUPTURE OF MEMBRANES


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Abstract

Background: Premature rupture of membranes is one of the known causes of preterm labor and accounts for approximately one-third of cases. Vitamin D deficiency may play a role in preterm labor, as well.

Objective: The present study aimed to compare vitamin D levels in mothers and infants with and without prolonged rupture of membranes (PROM).

Materials & Methods: This cross-sectional study was performed on 241 babies with and without a history of rupture of membranes in mothers, in the neonatal ward of Ghaem Hospital, Mashhad from 2019 to 2021 with available sampling method. After the confirmation of prolonged rupture of membranes (more than 18 hours before birth) based on history and examination with a speculum, we completed data collection tool, a checklist including laboratory evaluation and neonatal and maternal characteristics. The condition of the neonates with and without prolonged rupture of membranes was compared. Data were analyzed by T-test and Chi-square.

Results: We examined a total of 241 neonates including 148 (61.4%) without prolonged rupture of the membranes in mothers and 93 (38.6%) with PROM. There was a statistically significant difference between the two groups, maternal vitamin D level (P = 0.001), neonatal vitamin D level (P = 0.001), and fifth minute Apgar score (P = 0.003). This means that the values of these variables were lower in the group of neonates with PROM.

Conclusion: Vitamin D deficiency in mothers has been significantly associated with prolonged rupture of membranes and with increasing severity of vitamin deficiency, the probability of PROM increases and therefore rises the likelihood of preterm labor and its complications.

About the authors

H. Boskabadi

Мешхедский университет медицинских наук, Мешхед, Иран

Email: boskabadih@mums.ac.ir

Кафедра педиатрии, медицинский факультет, Мешхедский университет медицинских наук, Мешхед, Иран

Iran, Islamic Republic of

F. Rakhshanizadeh

Мешхедский университет медицинских наук, Мешхед, Иран

Email: RakhshanizadehF@mums.ac.ir

Кафедра педиатрии, медицинский факультет, Мешхедский университет медицинских наук, Мешхед, Иран

Iran, Islamic Republic of

M. Zakerihamidi

Исламский университет Азад, Тонекабон, Иран

Author for correspondence.
Email: maryamzakerihamidi@yahoo.co.nz
ORCID iD: 0000-0002-6543-9095

Кафедра акушерства, Школа медицинских наук, Филиал Тонекабон, Исламский университет Азад, Тонекабон, Иран

Iran, Islamic Republic of

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Copyright (c) 2022 Boskabadi H., Rakhshanizadeh F., Zakerihamidi M.

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