Parthenolide: suggested drug for COVID-19

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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the 2019 novel coronavirus (2019-nCoV) that causes acute respiratory distress syndrome (ARDS) which is the main reason for patients mortality. One of the effective treatments to reduce the effects of this virus is parthenolide (PN). Parthenolide is a sesquiterpene lactone found in medicinal plants. It can inhibit several pro-inflammatory signaling pathways, in particular the ATPase activity of NLRP3. Based on its ability to suppress inflammatory signal transduction and elevated level of serum IL-1β (a surrogate marker for NLRP3 activation) in COVID-19 patients, we suggest that PN could be potentiallyeffective for the treatment of COVID-19.

About the authors

M. Nemati

Urmia University of Medical Sciences

Email: mohadese.nemati@yahoo.com
ORCID iD: 0000-0002-4262-1636
Department of Biochemistry, School of Medicine.
Urmia Russian Federation

F. Danesh Pouya

Urmia University of Medical Sciences

Email: f_daneshpouya@hotmail.com
ORCID iD: 0000-0002-2636-9856
Department of Biochemistry, School of Medicine.

 

Urmia Iran, Islamic Republic of

E. Roshani Asl

Urmia University of Medical Sciences

Email: eli.roshani@yahoo.com
ORCID iD: 0000-0002-9783-5156
Department of Biochemistry, School of Medicine.

 

Urmia Iran, Islamic Republic of

Y. Rami

Urmia University of Medical Sciences

Author for correspondence.
Email: rasmiy@umsu.ac.ir
ORCID iD: 0000-0003-1506-1909
Yousef Rasmi - Department of Biochemistry, School of Medicine, Urmia University MS; Cellular and Molecular Research Center, Urmia UMS.

Urmia, Phone: +989143174740, Fax: +984432780801

Iran, Islamic Republic of

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Copyright (c) 2020 Nemati M., Danesh Pouya F., Roshani Asl E., Rami Y.

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