Rise in 2017-2018 measles morbidity in Serbia and Northwest Russia

Cover Page

Cite item

Abstract

In 2017, the WHO registered 23,927 measles cases in 44 out of 53 countries in the European region. In 2018, measles incidence rate increased up to 82,599 cases registered in 48 countries of the region, with a large number of measles-associated deaths. Overall, 72 measles fatalities were registered in 10 European countries, including Serbia (15 cases).

Aim of the study: to characterize 2017—2018 epidemiological upsurge of measles incidence rate observed in the Republic of Serbia (RS) and the Northwestern Federal District (NWFD) of the Russian Federation.

Materials and methods. During the 2017—2018 season, 944 serum samples were collected from patients with measles, rubella, or exanthematous diseases in the NWFD and tested in the Laboratory of Virology at the St. Petersburg Regional Centre for Measles Surveillance (SPbRC). In 2017—2018, 2,946 serum samples from the Republic of Serbia were analyzed in the SPbRC by using ELISA with IgM measles test system (Vector-Best, Russia; or Siemens, Germany). Urine and swab samples were examined by RT-PCR and used for isolation and genotyping of measles viruses.

Results. From 2017 to 2018, 5,798 measles cases were registered in the RS, among which 2,946 were laboratory-confirmed (serological testing and/or PCR). Unvaccinated subjects or those with unknown vaccination status accounted for majority of the cases. Children under 5 years of age and adults aged 30 years and over dominated among measles patients. During this season, 15 deaths were reported. Several genotypes of measles virus circulated in the RS, e.g. В3 Dublin, D8 Gir Somnath, and D8 Herborn. In 2018, 109 measles cases were recorded in the NWFD, 5 of which were imported from abroad. Among patients, adults comprised 64.2%, wherein 74.3% were covered by unvaccinated subjects or those with unknown vaccination status. Rise in measles incidence rate linked to multiple importations of various measles virus genotypes: В3 Kabul; B3 Dublin; D8 Frankfurt; D8 Cambridge; and D8 Gir Somnath.

About the authors

V. D. Stoiljkovic

Institute of Virology, Vaccine and Sera Torlak

Email: vstoiljkovic@torlak.rs
ORCID iD: 0000-0003-0097-9004

Acting Mananging Director of Institute for Virology.

Belgrade

M. A. Bichurina

St. Petersburg Pasteur Institute

Email: romanenkova@pasteurorg.ru
ORCID iD: 0000-0001-5184-0315

PhD, MD (Medicine), Head of the Virological Laboratory of Measles and Rubella Elimination.

St. Petersburg Russian Federation

I. N. Lavrentieva

St. Petersburg Pasteur Institute

Email: pasteur.lawr@mail.ru
ORCID iD: 0000-0002-2188-6547

PhD, MD (Medicine), Head of the Laboratory of Experimental Virology.

St. Petersburg Russian Federation

S. B. Filipovic-Vignjevic

Institute of Virology, Vaccine and Sera Torlak

Email: sfilipovic@torlak.rs
ORCID iD: 0000-0002-1373-6872

Director Assistant for Diagnostics and Scientific Development, Head of National Reference Laboratory for Influenza, Institute for Virology.

Belgrade

M. D. Bancevic

Institute of Virology, Vaccine and Sera Torlak

Email: mbancevic@torlak.rs
ORCID iD: 0000-0003-2364-9980

PhD, MD (Medicine), Specialist in Medical Microbiology, Head of National Reference Laboratory for Measles and Rubella, Department of Serology and Molecular Diagnostics.

Belgrade

N. V. Zheleznova

St. Petersburg Pasteur Institute

Email: nzhel@mail.ru
ORCID iD: 0000-0002-7072-1714

PhD (Biology), Leading Researcher, Laboratory of Viral Hepatitis.

St. Petersburg Russian Federation

A. Y. Antipova

St. Petersburg Pasteur Institute

Author for correspondence.
Email: anti130403@mail.ru
ORCID iD: 0000-0002-7763-535X

Anastasiya Yu. Antipova - PhD (Biology), Senior Researcher, Laboratory of Experimental Virology.

197101, St. Petersburg, Mira str., 14, Phone: +7 (812) 232-94-11 (office). Fax: +7 (812) 233-20-92

Russian Federation

References

  1. Бичурина М.А., Тимофеева Е.В., Железнова Н.В., Игнатьева Н.А., Шульга С.В., Лялина Л.В., Дегтярев О.В. Вспышка кори в детской больнице Санкт-Петербурга в 2012 году // Журнал инфектологии. 2013. Т. 5, № 2. С. 96—102.
  2. Результаты сертификации территорий СЗФО на отсутствие циркуляции эндемичного вируса кори: Аналитический обзор. СПб.: ФБУН НИИЭМ имени Пастера, 2012. 60 с.
  3. Совершенствование эпидемиологического надзора за корью в Северо-Западном федеральном округе России на этапе ликвидации инфекции: Аналитический обзор. ФБУН НИИЭМ имени Пастера, 2008. 52 с.
  4. Шульга С.В., Тихонова Н.Т., Наумова М.А. Изменение спектра циркулирующих генотипов вируса как показатель элиминации индигенной кори в России // Эпидемиология и вакцинопрофилактика. 2009. № 4. С. 4—9.
  5. Actual epidemiological situation of measles in Serbia. Belgrade: Institute of Public Health of Serbia, 2019. URL: http://www.batut.org.rs/index.php?content=1629 (03.08.2019).
  6. Andrianou X.D., Del Manso M., Bella A., Vescio M.F., Baggieri M., Rota M.C., Pezzotti P., Filia A. Spatiotemporal distribution and determinants of measles incidence during a large outbreak, Italy, September 2016 to July 2018. Euro Surveill, 2019, vol. 24, no. 17:1800679. doi: 10.2807/1560-7917.ES.2019.24.17.1800679
  7. Annual report on the immunization in the Republic of the Serbia in 2011. Belgrade: Institute of Public Health of Serbia. URL: http://www.batut.org.rs/download/izvestaji/Rezultati%20o%20sprovedenoj%20imunizaciji%202011 (03.08.2019).
  8. Filia A., Bella A., Del Manso M., Baggieri M., Magurano F., Rota M.C. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 — what is making elimination so difficult? Euro Surveill., 2017, vol. 22, no. 37: 30614. doi: 10.2807/1560-7917.ES.2017.22.37.30614
  9. Manual for the laboratory-based surveillance of measles, rubella, and congenital rubella syndrome. 3rd ed. WHO, 2018. URL: https://www.who.int/immunization/monitoring_surveillance/burden/laboratory/manual/en (15.12.2019).
  10. Manual for the laboratory diagnosis of measles and rubella virus infection. 2nd ed. Geneva: WHO, 2006. 22p.
  11. Measles update. Bulletin WHO. June 14, 2019. URL: https://www.who.int/csr/don/06-may-2019-measles-euro/en (08.10.2019).
  12. Nedeljkovic J., Rakic Adrovic S., Tasic G., Kovacevic-Jovanovic V., Loncarevic G., Hubschen J.M., Muller CP. Resurgence of measles in Serbia 2010—2011 highlights the need for supplementary immunization activities. Epidemiol. Infect., 2016, vol. 144, no. 5, pp. 1121-1128. doi: 10.1017/S0950268815002277
  13. Orenstein W.A., Hinman A., Nkowane B., Olive J.M., Reingold A. Measles and rubella global strategic plan 2012—2020 midterm review. Vaccine, 2018, vol. 36, suppl. 1, pp. A1-A34. doi: 10.1016/j.vaccine.2017.09.026
  14. Orosz L., Gaspar G., Rozsa A., Rakos N., Sziveri S., Bosnyakovits T. Epidemiological situation of measles in Romania, Italy, and Hungary: On what threats should we focus nowadays? Acta Microbiol. Immunol. Hung., 2018, vol. 65, no. 2, pp. 127-134. doi: 10.1556/030.65.2018.014
  15. Report on immunization conducted on the territory of the Republic of Serbia in 2018. URL: http://www.batut.org.rs/index.php?content=1900(In Serb.)
  16. Ristic M., Milosevic V., Medic S., Djekic Malbasa J., Rajcevic S., Boban J., Petrovic V. Seroepidemiological study in prediction of the risk groups for measles outbreaks in Vojvodina, Serbia. PLoS One, 2019, vol. 14, no. 5: e0216219. doi: 10.1371/journal.pone.0216219
  17. Seguljev Z., Buric P., Petrovic V., Stefanovic S., Cosic G., Hrnjakovic I.C., Milosevic V., Karagiannis I., Boxall N., Jankovic D. Current measles outbreak in Serbia: a preliminary report. Euro Surveill., 2007, vol. 12, no. 11: E070315.2. doi: 10.2807/esw.12.11.03155-en
  18. Tamura K., Stecher G., Peterson D., Filipski A., Kumar S. MEGA 6: molecular evolutionary genetics analysis version 6.0. Mol. Biol. Evol, 2013, vol. 30, no. 12, pp. 2725-2759. doi: 10.1093/molbev/mst197
  19. The results of conducted immunization in the Republic of Serbia in 2015—2016. Belgrade: Institute of Public Health of Serbia, 2016. 57p. (In Serb.)
  20. World Health Organization. Eliminating measles and rubella and preventing congenital rubella infection: WHO European Region strategic plan 2005—2010. URL: http://www.euro.who.int/data/assets/pdf_file/0008/79028/E87772.pdf
  21. World Health Organization. Genetic diversity of wild-type measles viruse and the global measles nucleotide surveillance database (MeaNS). Wkly Epid. Rec., 2015, vol. 90, no. 30, pp. 373-380.
  22. World Health Organization. Global Vaccine Action Plan 2011—2020. URL: http://www.who.int/immunization/global_vaccine_ac-tion_plan/GVAP_doc_2011_2020/en
  23. World Health Organization. Measles virus nomenclature update: 2012. Wkly Epid. Rec., 2012, vol. 87, no. 9, pp. 73-80.
  24. Zimmerman L.A., Muscat M., Singh S., Ben Mamou M., Jankovic D., Datta S., Alexander J.P., Goodson J.L., O’Connor P. Progress Toward Measles Elimination — European Region, 2009-2018. MMWR, 2019, vol. 68, no. 17, pp. 396-401.

Copyright (c) 2020 Stoiljkovic V.D., Bichurina M.A., Lavrentieva I.N., Filipovic-Vignjevic S.B., Bancevic M.D., Zheleznova N.V., Antipova A.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies