Immunity to measles virus in diverse population groups

Cover Page

Cite item

Abstract

The aim of the study was to assess the measles immunity level among employees of medical organizations of various specialties, young subjects, and neonates. Materials and Methods. The measles immunity status was assessed for all the employees of St. Petersburg State Budgetary Healthcare Institution Maternity Hospital No. 10 (386 subjects), civilian medical staff of the clinics of the Military Medical Academy named after S.M. Kirov (Military Medical Academy) (1399 subjects), cadets of the Military Medical Academy (304 subjects) and 34 neonates. Laboratory testing was performed by using ELISA with test kits “VektoKor-IgG” (RF). Results. Medical workers displayed high total level of protection against measles virus serologically confirmed in 87.5% of the maternity hospital staff and 81.6% of the employees at the Military Medical Academy clinics. No differences in the immune status between the varying categories of medical personnel from the departments of various specialties were revealed. Lower population immunity was observed in the 20-40-year age group. Among the employees of the maternity hospital, the proportion of measles virus seropositive subjects aged 20—40 years was 75.9% (95%, CI 67.2—82.9%), 40—59 years — 91.5% (95%, CI 86.7—94.7%), 60 year and older subjects were all seropositive (95%, CI 94.6—100%). Dual vaccination did not guarantee emergence of effective measles immunity. The majority of seronegative subjects were dually vaccinated, hence, even in case of previous dual measles vaccination, it is necessary to perform a serological examination prior to recruitment to medical facilities. Females comprised more than 90% of medical workers. Therefore, women of fertile age previously dually vaccinated, but immunologically seronegative, are at risk of measles and intrauterine fetal infection, as well as the risk of its development is increased in vaccination age children. It was confirmed by demonstrating that as few as 70.6±15.3% of neonates were immune to the measles virus. The proportion of seronegative infants (29.4±15.3%) was comparable to that one in seronegative subjects aged 20—40 years (24.1±8.1%) working at the maternity hospital. Among the younger age group (aged 18—23 years) such as cadets of the Military Medical Academy, a significantly higher proportion of seronegative individuals was found — 48.3±5.6%, thereby increasing probability for measles outbreak therein. Conclusions. In order to eradicate measles, it is necessary to develop a screening program for detecting antibodies against measles among young and middle-aged subjects.

About the authors

A. V. Liubimova

North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: lubimova@gmail.com

Anna V. Liubimova - PhD, MD (Medicine), Associate Professor, Professor of the Department of Epidemiology, Parasitology and Desinfectology, North-Western State Medical University named after I.I. Mechnikov.

191015, St. Petersburg, Kirochnaya str., 41.

Phone: +7 (906) 244-83-22

Russian Federation

M. D. Zlokazov

North-Western State Medical University named after I.I. Mechnikov; Maternity Hospital No. 10

Email: 89811064889@mail.ru

PhD Student of the Department of Epidemiology, Parasitology and Desinfectology, North-Western State Medical University named after I.I. Mechnikov

St. Petersburg.

Russian Federation

L. A. Ivanova

Maternity Hospital No. 10

Email: lada.russia.spb@mail.ru

PhD (Medicine), Head Physician of the Maternity Hospital No. 10.

St. Petersburg.

Russian Federation

L. YU. Arzamastseva

Municipal Polyclinic No. 91

Email: p50.epid@zdrav.spb.ru

Epidemiologist, Municipal Polyclinic No. 91.

St. Petersburg.

Russian Federation

N. N. Ryzhman

Military Medical Academy named after S.M. Kirov

Email: ryzhman@mail.ru

PhD (Medicine), Deputy Head of the Clinical Research Academy, Military Medical Academy named after S.M. Kirov.

St. Petersburg.

Russian Federation

E. N. Kolosovskaya

North-Western State Medical University named after I.I. Mechnikov; Military Medical Academy named after S.M. Kirov

Email: lubimova@gmail.com

PhD, MD (Medicine), Head of the Department of Sanitary and Epidemiological Surveillance for Hospital Infection, Military Medical Academy named after S.M. Kirov; Professor of the Department of Epidemiology, Parasitology and Desinfectology, North-Western State Medical University named after I.I. Mechnikov.

St. Petersburg.

Russian Federation

O. P. Gumilevskaya

Military Medical Academy named after S.M. Kirov

Email: ogum@mail.ru

PhD, MD (Medicine), Head of the Clinical Laboratory Diagnostics Centre, Military Medical Academy named after S.M. Kirov.

St. Petersburg.

Russian Federation

References

  1. Астапов А.А., Мельникова В.Н., Свирчевская Е.Ю. Корь у новорожденного ребенка // Здравоохранение. 2013. № 2. С. 62-63.
  2. Долбин Д.А., Хайруллин Р.З. Иммунологическая прослойка к вирусу кори у медицинских работников // Научный альманах. 2015. Т. 9, № 11. С. 954-956. doi: 10.17117/na.2015.09.954
  3. Об эпидемической ситуации по кори. Федеральная служба по надзору в сфере защиты прав потребителей и благополучия человека. 23.08.2018. URL: http://www.rospotrebnadzor.ru/about/info/news/news_details.php?ELEMENT_ID=10555&sphrase_id=1479622
  4. Тихонова Н.Т., Цвиркун О.В., Герасимова А.Г., Басов А.А., Фролов Р.А., Ежлова Е.Б., Мельникова А.А., Ватолина А.А., Иванников Н.Ю., Мельник Т.Н., Захарян А.И. Состояние специфического иммунитета к вирусам кори и краснухи у новорожденных и их матерей // Эпидемиология и вакцинопрофилактика. 2017. Т. 16, № 6. С. 14-20. doi: 10.31631/2073-3046-2017-16-6-14-20
  5. Fiebelkorn A.P., Seward J.F., Orenstein W.A. A global perspective of vaccination of healthcare personnel against measles: systematic review. Vaccine, 2014, vol. 32, no. 38, pp. 4823—4839. doi: 10.1016/j.vaccine.2013.11.005
  6. Filia A., Bella A., Del Manso M., Baggieri M., Magurano F., Rota M.C. Ongoing outbreak with well over 4,000 measles cases in Italy from January to end August 2017 — what is making elimination so difficult? EuroSurveill, 2017, vol. 22, no. 37: 30614. doi: 10.2807/1560-7917.ES.2017.22.37.30614
  7. Guerra F.M., Crowcroft N.S., Friedman L., Deeks S.L., Halperin S.A., Severini A., Hatchette T.F., Bolotin S.; Immunity of Canadians and Risk of Epidemics (iCARE) Network. Waning of measles maternal antibody in infants in measles elimination settings — a systematic literature review. Vaccine, 2018, vol. 36, no. 10, pp. 1248—1255. doi: 10.1016/j.vaccine.2018.01.002
  8. Coughlin M.M., Beck A.S., Bankamp B., Rota P.A. Perspective on global measles epidemiology and control and the role of novel vaccination strategies. Viruses, 2017, vol. 9, no. 1: 11. doi: 10.3390/v9010011
  9. Plans P., de Ory F., Campins M., Alvarez E., Paya T., Guisasola E., Compte C., Vellbe K., Sanchez C., Lozano M.J., Aran I., Bonmati A., Carreras R., Jane M., Cabero L. Prevalence ofanti-rubella, anti-measles and anti-mumps IgG antibodies in neonates and pregnant women in Catalonia (Spain) in 2013: susceptibility to measles increased from 2003 to 2013. Eur J Clin. Microbiol. Infect Dis, 2015, vol. 34, no. 6, pp. 1161-1171. doi: 10.1007/s10096-015-2339-4

Supplementary files

There are no supplementary files to display.


Copyright (c) 2020 Liubimova A.V., Zlokazov M.D., Ivanova L.A., Arzamastseva L.Y., Ryzhman N.N., Kolosovskaya E.N., Gumilevskaya O.P.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies