Intestinal microbiota composition and peripheral blood Th cell subsets in patients with multiple sclerosis

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Abstract

At present, the role of intestinal microbiota in diverse diseases of the central nervous system, including of multiple sclerosis (MS) has been extensively investigated. Self-reactive CD4+ Th1 and Th17 cells specific to myelin-derived antigens play a key role in the MS pathogenesis. Taking into consideration pathogenetic features related to MS development, we examined a relation between intestinal microbiocenosis and abundance of various peripheral blood helper T (Th) cell subsets in MS patients. Objective of the study: to assess prevalence of individual members of the intestinal microbiota in MS patients and analyze a relation with peripheral blood Th cell subsets. Prevalence of symbiotic and opportunistic microbial species was estimated by bacteriological method and real time PCR in 112 MS patients (72 females, 40 males) of varying severity and duration. Th cell subsets (Th1, Th2, Th17, Th1/Th17, Th17/Th22, DP Th17) were analyzed by using multi-color flow cytometry based on Th cell subset-specific surface expression of chemokine receptors. A relationship between individual intestinal microbiota species and severity, duration and rate of MS progression, as well as with the phenotype of immune cells was assessed. It was found that the most significant correlation between percentage of peripheral blood Th cell subsets was observed with prevalence of Lactobacillus spp., Enterococcus spp. and Enterobacter spp. Moreover, prevalence of Enterococcus spp. Th cell composition influenced synergistically or antagonistically together with Enterobacter spp. or Lactobacillus spp., respectively. It is suggested that direct and indirect impact of intestinal microbiota composition on human immune system might contribute to developing novel strategies for treating MS.

About the authors

I. N. Abdurasulova

Institute of Experimental Medicine;
St. Petersburg State Pediatric Medical University

Author for correspondence.
Email: i_abdurasulova@mail.ru

PhD (Biology), Leading Researcher, Pavlov Department of Physiology;

Associate Professor, Department of Medical Biophysics, 

197376, St. Petersburg, Akademika Pavlova str., 12

Russian Federation

E. A. Tarasova

Institute of Experimental Medicine

Email: tarasovahellen@mail.ru

Researcher, Pavlov Department of Physiology,

St. Petersburg

Russian Federation

I. V. Kudryavtsev

Institute of Experimental Medicine;
Pavlov First St. Petersburg State Medical University

Email: igorek1981@yandex.ru

PhD (Biology), Senior Researcher, Laboratory of Immunology;

Associate Professor, Department of Immunology,

St. Petersburg

Russian Federation

I. G. Negoreeva

Institute of the Human Brain RAS

Email: nip@ihb.spb.ru

PhD (Medicine), Researcher, Laboratory of Neuroimmunology,

St. Petersburg

Russian Federation

A. G. Ilves

Institute of the Human Brain RAS

Email: ailves@hotmail.com

PhD (Medicine), Senior Researcher, Laboratory of Neuroimmunology,

St. Petersburg

Russian Federation

M. K. Serebriakova

Institute of Experimental Medicine

Email: m-serebryakova@yandex.ru

Researcher, Department of Immunology,

St. Petersburg

Russian Federation

E. I. Ermolenko

Institute of Experimental Medicine
St. Petersburg State University

Email: lermolenko1@yandex.ru

PhD, MD (Medicine), Head of the Laboratory of Biomedical Microecology,

St. Petersburg

Russian Federation

E. V. Ivashkova

Institute of the Human Brain RAS

Email: ivashkova@ihb.spb.ru

PhD (Medicine), Researcher, Laboratory of Neuroimmunology,

St. Petersburg

Russian Federation

A. V. Matsulevich

Institute of Experimental Medicine

Email: cat_fly@bk.ru

Researcher, Pavlov Department of Physiology,

St. Petersburg

Russian Federation

A. E. Tatarinov

Institute of Experimental Medicine

Email: alex2ta@mail.ru

Head of the Neurological Department, Institute of Experimental Medicine,

St. Petersburg

Russian Federation

I. D. Stoliarov

Institute of the Human Brain RAS

Email: sid@ihb.spb.ru

PhD, MD (Medicine), Professor, Head of Laboratory of Neuroimmunology,

St. Petersburg

Russian Federation

V. M. Klimenko

Institute of Experimental Medicine

Email: klimenko_victor@mail.ru

PhD, MD (Medicine), Professor, Head of Pavlov Department of Physiology, 

St. Petersburg

Russian Federation

A. N. Suvorov

Institute of Experimental Medicine;
St. Petersburg State University

Email: alexaner_suvorov1@hotmail.com

Head of the Department of Molecular Microbiology;

RAS Corresponding Member, PhD, MD (Medicine), Professor, Head of the Department of Fundamental Problems of Medicine and Medical Technologies, Faculty of Dentistry and Medical Technologies,

St. Petersburg

Russian Federation

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Copyright (c) 2019 Abdurasulova I.N., Tarasova E.A., Kudryavtsev I.V., Negoreeva I.G., Ilves A.G., Serebriakova M.K., Ermolenko E.I., Ivashkova E.V., Matsulevich A.V., Tatarinov A.E., Stoliarov I.D., Klimenko V.M., Suvorov A.N.

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