PhD (Biology), Associate Professor, Department of Genetics and Fundamental Medicine
кандидат биологических наук, доцент кафедры генетики и фундаментальной медицины
DSc (Medicine), Associate Professor, Head of the Department of Otorhinolaryngology
доктор медицинских наук, доцент, зав. кафедрой оториноларингологии
Assistant Professor, Department of Morphology and Forensic Medicine, Engineer-Technologist, Laboratory of Cytogenetics
ассистент кафедры морфологии и судебной медицины, инженер-технолог лаборатории цитогенетики
PhD (Biology), Associate Professor
кандидат биологических наук, доцент кафедры генетики и фундаментальной медицины
DSc (Medicine), Associate Professor, Professor of the Department of Genetics and Fundamental Medicine
доктор медицинских наук, доцент, профессор кафедры генетики и фундаментальной медицины
Prevention of respiratory infections during epidemic periods is an important task of modern health care in Russia and worldwide. One of such approach may rely on use of volatile substances capable of activating nonspecific resistance of the nasal mucosa. Long-term application of synthetic analogues of female pheromones to young males leads to lowered morbidity of respiratory diseases, increased levels of secretory immunoglobulins, as well as decrease peripheral blood of eosinophilia levels in subjects with allergic diseases. Based on this, the aim of the study was set to study an impact of anamnesis factors and indicators reflecting the functioning of nasal mucosal immunity, its nonspecific resistance, on emerging frequent respiratory morbidity; as well as to evaluate effectiveness of natopherine- and andropherine-containing odorants regarding dynamics of such indicators and to reduce incidence of respiratory infections in young subjects. Materials and methods. There were examined 46 apparently healthy boys and girls aged 18 to 22 years. The frequency of respiratory morbidity, anamnesis factors, and the results of non-invasive studies (cytokine concentrations in the nasopharyngeal aspirate and rhinocytograms). Within 30 days, all young subjects were applied to the nasolabial fold synthetic analogues of male (andropherine) and female (natopherine) pheromones (andropherine — for young female, natopherine — for young male). A re-examination with the above mentioned studies was carried out on day 14 and day 30 of the study. The incidence of respiratory infections was reassessed one year after the onset. Results. The study showed identified a number of predictors and protectors of frequent and long-term respiratory morbidity in young subjects. The predictors of this condition were presented by catamnestics markers of allergic anomalies of the constitution, behavioral factors (smoking), as well as immune indicators of allergy (IL-4) and mucociliary clearance deficiency. A monthly course of odorant applications on the skin of the nasolabial fold using synthetic analogues of male and female pheromones (steranes) has a positive effect both on the nonspecific resistance of the nasal mucosa as well as on the immune parameters. After a month of using steranes, the nasal mucosa is completely decontaminated from coccal microorganisms, and over the next 12 months, the frequency of respiratory infections decreases. This indicates about a prominent clinical effect of the odorants applied.
Профилактика респираторных инфекций в эпидемические периоды является важной задачей современного здравоохранения России и мира. Одним из таких подходов может быть использование летучих веществ, способных активировать неспецифическую резистентность слизистой оболочки носа. Длительная аппликация синтетических аналогов женских феромонов молодым мужчинам приводит к снижению частоты респираторных заболеваний, повышению уровней секреторных иммуноглобулинов, а у лиц с аллергическими заболеваниями — к снижению уровней эозинофилии в периферической крови. Исходя из этого поставлена цель исследования — изучить влияние факторов анамнеза и показателей, отражающих функционирование мукозального иммунитета слизистой оболочки носа, ее неспецифической резистентности, на формирование частой респираторной заболеваемости; а также оценить эффективность одорантов с натоферином и андроферином в отношении динамики этих показателей и снижения частоты респираторных инфекций у молодых людей.