Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI7710.15789/2220-7619-2012-3-615-626REVIEWSОБЗОРЫMOLECULAR-GENETIC BASIS OF PHYSIOLOGY AND PATHOGENICITY OF COXIELLA BURNETIIМОЛЕКУЛЯРНО-ГЕНЕТИЧЕСКИЕ ОСНОВЫ ФИЗИОЛОГИИ И ПАТОГЕННОСТИ COXIELLA BURNETIIPanpherovaYu. A.ПанфероваЮ. А.
Russian Federation

научный сотрудник лаборатории зооантропонозов

197101, Санкт-Петербург, ул. Мира, 14

zoonoses@mail.ruФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург02072012236156260207201402072014Copyright ©; 2014, Panpherova Y.A.Copyright ©; 2014, Панферова Ю.А.2014Panpherova Y.A.Панферова Ю.А.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/77

Abstract. The agent of Q-fever Coxiella burnetii is unusual intracellular pathogen which is possessed of biggest transporting and metabolic abilities in compare with microorganisms with similar parasitic strategy. It is supposed that different strains of the pathogen exist in various stages of pathological adaption and have different potential of virulence. The structure of C. burnetii genome, characteristics of metabolic routes, mechanisms of interaction with host cells and possible virulence factors are discussed in the review. The special attention is paid to Coxiella genotyping methods and possible correlations between genomic polymorphism of different strains and their virulence potential.

Резюме. Возбудитель Ку-лихорадки, Coxiella burnetii, является достаточно необычным внутриклеточным патогеном, обладающим значительно большими транспортными и метаболическими способностями, нежели микроорганизмы со сходной паразитической стратегией. Предполагается, что разные штаммы патогена находятся на разных стадиях процесса патоадаптации и обладают различным вирулентным потенциалом. В обзоре рассматривается структура генома C. burnetii, особенности метаболических путей, механизмы взаимодействия с клеткой хозяина и возможные факторы вирулентности. Особое внимание уделяется методам генотипирования коксиелл и возможной корреляции между геномным полиморфизмом различных штаммов и их вирулентным потенциалом.

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