Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI6210.15789/2220-7619-2011-4-293-302REVIEWSОБЗОРЫUSING OF MOUSE MODEL TO ANALYZE IMMUNE RESPONSE TO INFECTIOUS PATHOGENS BY THE METHODS OF CLASSICAL GENETICSИСПОЛЬЗОВАНИЕ МЫШИНОЙ МОДЕЛИ ДЛЯ АНАЛИЗА ИММУННОГО ОТВЕТА К ИНФЕКЦИЯМ МЕТОДАМИ КЛАССИЧЕСКОЙ ГЕНЕТИКИPoltorakA.ПолторакА.United States
Assistant Professor of Pathology, Graduate Program in Immunology, Graduate Program in Genetics
Abstract. Identification and studying of numerous functions of all genes of the human beings is one of the main objects of modern biological science. Due to high level of homology between mouse and human genomes the important role to reach above mentioned goal belongs to the mouse model which using in the classical genetics increase in connection with appearance of different inbred mouse lines. For instance, the differences in immune response to infectious pathogens in various mouse lines were used many times to determine immunologically competent genes. That is why the contribution of mouse model in understanding of the mechanisms of immune response to infectious pathogens is difficult to overestimate. In the current review some of the most successful and well known examples of mouse using in studies of anti-infectious response are described.
Резюме. Установление и изучение многочисленных функций всех генов человека является одной из главных задач современной биологической науки. Вследствие высокой степени гомологии между мышиным и человеческим геномами, важная роль в решении этой задачи принадлежит мышиной модели, использование которой в классической генетике особенно возросло в связи с выведением различных инбредных мышиных линий. Так, например, различия в иммунном ответе к инфекциям в разных мышиных линиях были неоднократно использованы для нахождения иммунологически компетентных генов. Именно поэтому трудно переоценить вклад мышиной модели в понимание механизмов иммунного ответа к инфекциям. В данном обзоре приведены некоторые из наиболее успешных и известных примеров использования мышей в изучении противоинфекционного ответа.
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