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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Infection and Immunity</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Infection and Immunity</journal-title><trans-title-group xml:lang="ru"><trans-title>Инфекция и иммунитет</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2220-7619</issn><issn publication-format="electronic">2313-7398</issn><publisher><publisher-name xml:lang="en">SPb RAACI</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">57</article-id><article-id pub-id-type="doi">10.15789/2220-7619-2011-3-267-270</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">CHRONIC FATIGUE SYNDROME: APPROACHES TO DIAGNOSTICS AND THERAPY</article-title><trans-title-group xml:lang="ru"><trans-title>СИНДРОМ ХРОНИЧЕСКОЙ УСТАЛОСТИ: ПОДХОДЫ К ДИАГНОСТИКЕ И ТЕРАПИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kalinina</surname><given-names>N. M.</given-names></name><name xml:lang="ru"><surname>Калинина</surname><given-names>Н. М.</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д.м.н., профессор, зав лабораторией иммунологии</p><p>194044, Санкт-Петербург, ул. Акад. Лебедева, 4/2</p></bio><email>kalinina@arcerm.spb.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГУЗ Всероссийский центр экстренной и радиационной медицины им. А.М. Никифорова МЧС России, Санкт-Петербург</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2011</year></pub-date><volume>1</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>267</fpage><lpage>270</lpage><history><date date-type="received" iso-8601-date="2014-06-30"><day>30</day><month>06</month><year>2014</year></date><date date-type="accepted" iso-8601-date="2014-06-30"><day>30</day><month>06</month><year>2014</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2014, Kalinina N.M.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2014, Калинина Н.М.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder xml:lang="en">Kalinina N.M.</copyright-holder><copyright-holder xml:lang="ru">Калинина Н.М.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://iimmun.ru/iimm/article/view/57">https://iimmun.ru/iimm/article/view/57</self-uri><abstract xml:lang="en"><p><bold>Abstract.</bold> The data on clinical symptoms in patients with chronic fatigue syndrome (CFS) as well as some immunopathogenesis mechanisms of this disease are discussed in the article. Moreover, own research results on immunological changes in CFS patients have been described.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Резюме.</bold> В статье представлены данные о клинической симптоматике при синдроме хронической усталости (СХУ), некоторые механизмы иммунопатогенеза и собственные данные об иммунологических нарушениях у пациентов с СХУ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chronic fatigue syndrome</kwd><kwd>immune inflammation</kwd><kwd>Epstain–Barr virus</kwd><kwd>Herpes virus 6</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вирус Эпштейна–Барр</kwd><kwd>вирус герпеса 6 типа</kwd><kwd>иммунное воспаление</kwd><kwd>синдром хронической усталости</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>1.	Cameron B., Hirschberg D.L., Rosenberg-Hassan Y., Ablashi D., Lloyd A.R. Serum cytokine levels in postinfective fatigue syndrome // Clin. Infect. 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