Russian Journal of Infection and ImmunityRussian Journal of Infection and Immunity2220-76192313-7398SPb RAACI183210.15789/2220-7619-COT-1832Research ArticleState of anti-rubella virus population immunity in the Republic of Belarus and Russian FederationTsvirkunO. V.<p>PhD, MD (Medicine), Head of the Epidemiology Department, Associate Professor, Department of Infectious Diseases with Courses in Epidemiology and Phthisiology</p>o.tsvirkun@gabrich.ruSamoilovichE. O.<p>PhD, MD (Medicine), Professor, Head of the Laboratory of Vaccine Preventable Diseases</p>esamoilovich@gmail.comTikhonovaN. T.<p>PhD, MD (Biology), Professor, Head Researcher, Laboratory of Cytokines</p>tikhmail@mail.ruGerasimovaA. G.<p>PhD (Medicine), Leading Researcher, Laboratory of Viral Infections Prophylaxis</p>4521809@mail.ruTuraevaN. V.<p>PhD (Medicine), Head of the Laboratory for Viral Infections Prevention</p>natalya-turaeva@yandex.ruErmolovichM. A.<p>PhD, MD (Medicine), Head Researcher, Laboratory of Vaccine Preventable Diseases</p>yermalovich@mail.ruSemeikoG. V.<p>PhD (Biology), Leading Researcher, Laboratory of Vaccine Preventable Diseases</p>g-semeiko@yandex.ru.N. Gabrichevsky Research Institute for Epidemiology and MicrobiologyPeoples’ Friendship University of RussiaRepublican Research and Practical Center for Epidemiology and MicrobiologyG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology161120221259099182711202128072022Copyright © 2022, Tsvirkun O.V., Samoilovich E.O., Tikhonova N.T., Gerasimova A.G., Turaeva N.V., Ermolovich M.A., Semeiko G.V.2022<p>To confirm a progress towards the rubella elimination, immunization coverage indicators and the results of serological studies are used. At the same time, the most objective method of assessing collective immunity is a serological examination. The purpose of this work was to compare the results of assessing state of population immunity against rubella virus in the Republic of Belarus and the Russian Federation using various vaccines and different approaches to study organization and cohort selection screening and monitoring. 2019 laboratory studies to determine IgG antibodies against rubella virus were carried out by ELISA method of the unified enzyme immunoassay system Ecolab (Russia). The serum study results of 701 subjects aged 245 years from all the 7 regions of the Republic of Belarus (screening study) and 55 082 subjects aged 349 years (monitoring) from 85 regions of the Russian Federation were analyzed. The results were evaluated in three age groups children, adults, total cohort by using a threshold level of 8385% seropositive individuals sufficient to prevent virus transmission. The antigenic composition of the rubella component in the mono- and complex vaccines respectively used in the Russian Federation and the Republic of Belarus is identical, which allows to compare the state of population immunity against rubella virus therein without taking into account an influence of the vaccine strain. Studies have shown that while using varying vaccine preparations and approaches to organization of serological examination, both in the Republic of Belarus and the Russian Federation, rubella virus-specific IgG level was detected at rather high level in all age groups comprising more than 90%. The portion of rubella seropositive subjects in entire country was 95.44% in the Republic of Belarus and 97.14% in the Russian Federation. Moreover, the level of specific antibodies remains high, despite the low incidence rate and absence of booster effect in both countries. The mean group antibody concentration in seropositive patients in all age groups was quite high and exceeded the minimum protective concentration (11 IU/ml) by 10 or more times. The data obtained indicate the legitimacy of using a serological study of collective rubella immunity as a routine or seromonitoring as well as periodic or screening investigation.</p>rubellaimmunityseroprevalencepopulationmonitoringscreeningкраснухаиммунитетсеропревалентностьпопуляциямониторингскрининг[О состоянии санитарно-эпидемиологического благополучия населения в Российской Федерации в 2019 году: Государственный доклад. [On the state of sanitary and epidemiological welfare of the population in the Russian Federation in 2019: state report. (In Russ.)] URL: https://www.rospotrebnadzor.ru/upload/iblock/8e4/gosdoklad-za-2019_seb_29_05.pdf (03.11.2021)][Самойлович Е.О. Надзор за вакциноуправляемыми инфекциями в Республике Беларусь: соответствие международным стандартам // Здравоохранение. 2014. № 6. С. 7–11. 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