Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI179210.15789/2220-7619-COV-1792ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИResearch ArticleComparison of vitamin D levels between mothers and infants with and without prolonged membrane ruptureСравнение уровней витамина D у матерей и новорожденных с длительным преждевременным разрывом плодных оболочек и без негоBoskabadiH.БоскабадиХ.
Iran, Islamic Republic of

Professor, Department of Pediatrics, Faculty of Medicine

профессор кафедры педиатрии, факультет медицины

boskabadih@mums.ac.irRakhshanizadehF.РахшанизадеФ.
Iran, Islamic Republic of

Assistant Professor of Pediatrics, Department of Pediatrics, Faculty of Medicine

ассистент кафедры педиатрии, факультет медицины

RakhshanizadehF@mums.ac.irhttps://orcid.org/0000-0002-6543-9095ZakerihamidiMaryamЗакерихамидиМарьям
Iran, Islamic Republic of

PhD (Reproductive Health), Assistant Professor of Reproductive Health, Department of Midwifery, Faculty of Medical Sciences

кандидат наук (репродуктивное здоровье), доцент кафедры акушерства факультета медицинских наук

maryamzakerihamidi@yahoo.co.nzMashhad University of Medical SciencesМешхедский университет медицинских наукIslamic Azad University, Tonekabon BranchИсламский университет Азад, филиал Тонкабон12042022040720221235565620109202103022022Copyright ©; 2022, Boskabadi H., Rakhshanizadeh F., Zakerihamidi M.Copyright ©; 2022, Боскабади Х., Рахшанизаде Ф., Закерихамиди М.2022Boskabadi H., Rakhshanizadeh F., Zakerihamidi M.Боскабади Х., Рахшанизаде Ф., Закерихамиди М.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/1792

Background. Premature membrane rupture is a known causes of preterm labor and accounts for approximately one-third of cases. Vitamin D deficiency may play a role in preterm labor as well. Objective. The present study aimed to compare vitamin D levels in mothers and infants with and without prolonged rupture of membranes (PROM). Materials and methods. This cross-sectional study was conducted with 241 babies, with and without a history of membrane rupture, in mothers in the neonatal ward of Ghaem Hospital, Mashhad, from 2019 to 2021 with available sampling methods. After confirmation of prolonged membrane rupture (more than 18 hours before birth) based on history and examination with a speculum, we completed a data collection tool, a checklist including laboratory evaluation and neonatal and maternal characteristics. The conditions of neonates with and without prolonged membrane rupture were compared. Data were analyzed by T-test and Chi-square. Results. We examined a total of 241 neonates including 148 (61.4%) without prolonged rupture of the membranes in mothers and 93 (38.6%) with PROM. There were statistically significant differences between the two groups regarding: maternal vitamin D level (p = 0.001); neonatal vitamin D level (p = 0.001); and fifth minute Apgar score (p = 0.003). These variables were lower in the group of neonates with PROM. Conclusion. Vitamin D deficiency in mothers was significantly associated with prolonged membrane rupture. With increasing severity of vitamin D deficiency, the probability of PROM increases and, therefore, the likelihood of preterm labor and its complications rises.

Актуальность. Преждевременный разрыв плодных оболочек является одной из причин преждевременных родов и сопровождает примерно одну треть всех родов. Дефицит витамина D также может играть роль в развитии преждевременных родов. Целью настоящего исследования было сравнение уровней витамина D у матерей и младенцев с длительным преждевременным разрывом плодных оболочек и без него. Материалы и методы. В настоящее исследование был включен 241 младенец, рожденный на фоне длительного преждевременного разрыва плодных оболочек (ПРПО) и без такового в неонатальном отделении больницы Гаем, Мешхед, с 2019 по 2021 г. После подтверждения ПРПО (более 18 часов до рождения) на основании анамнеза и осмотра с помощью зеркал, было проведено лабораторное исследование и зафиксированы показатели новорожденного и матери. Сравнивали состояние новорожденных с длительным ПРПО и без такового. Статистическую обработку данных проводили, определяя критериев Стьюдента и Пирсона (хи-квадрат). Результаты. Обследован 241 новорожденный, в том числе 93 (38.6%) рожденных на фоне длительного ПРПО и 148 (61.4%) без ПРПО. Между двумя группами обнаружена статистически значимая разница в уровне витамина D у матери (p = 0.001), в уровне витамина D у новорожденного (p = 0.001) и в оценке по шкале Апгар на пятой минуте (p = 0.003). Это означает, что величины указанных переменных были ниже в группе новорожденных с ПРПО. Вывод. Длительный ПРПО в значительной степени коррелирует с дефицитом витамина D у матерей, а с усилением тяжести дефицита витамина D увеличивается вероятность ПРПО и, следовательно, повышается вероятность преждевременных родов и их осложнений.

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