Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI178310.15789/2220-7619-EOS-1783ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИResearch ArticleEvaluation of serum levels of IL-6 and adiponectin in COVID-19 patients and their relationship with disease severityОценка сывороточных уровней IL-6 и адипонектина у пациентов с COVID-19 и их связи с тяжестью заболеванияNorouzianMarziehНорузянМарзи
Iran, Islamic Republic of

Assistant Professor of Medical Immunology, Department of Laboratory Sciences, School of Allied Medical Sciences

доцент кафедры медицинской иммунологии, факультет лабораторных наук, Школа смежных медицинских наук

marzieh.norouzi@gmail.comSharifi-SarasiabiKhojastehШарифи-СарасиабиК.
Iran, Islamic Republic of

Infectious and Tropical Diseases Research Center, Hormozgan Health Institute

Исследовательский центр инфекционных и тропических болезней, Хормозганский институт здоровья

sharifisarasiabi@gmail.comNajafi-AslMajidНаджафи-АслМ.
Iran, Islamic Republic of

Department of Laboratory Sciences, School of Allied Medical Sciences, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; Infectious and Tropical Diseases Research Center, Hormozgan Health Institute

кафедра лабораторных наук, Школа смежных медицинских наук, Хормозганский университет медицинских наук, г. Бандар-Аббас, Иран; Исследовательский центр инфекционных и тропических болезней, Хормозганский институт здоровья

najafiasl2015@gmail.comHassani AzadM.Хассани АзадМ.
Iran, Islamic Republic of

Infectious and Tropical Diseases Research Center, Hormozgan Health Institute

Исследовательский центр инфекционных и тропических болезней, Хормозганский институт здоровья

mehdihassaniazad@gmail.comEstabraghnia BabakiH.Эстабрагния БабакиХ.
Iran, Islamic Republic of

Department of Internal Medicine, Shahid Mohammadi Hospital, Faculty of Medicine

отделение внутренней медицины, больница Шахид Мохаммади, медицинский факультет

h.estabragh@gmail.comHormozgan University of Medical SciencesГормозганский университет медицинских наук12052022040720221235115183007202111032022Copyright ©; 2022, Norouzian M., Sharifi-Sarasiabi K., Najafi-Asl M., Hassani Azad M., Estabraghnia Babaki H.Copyright ©; 2022, Норузян М., Шарифи-Сарасиаби К., Наджафи-Асл М., Хассани Азад М., Эстабрагния Бабаки Х.2022Norouzian M., Sharifi-Sarasiabi K., Najafi-Asl M., Hassani Azad M., Estabraghnia Babaki H.Норузян М., Шарифи-Сарасиаби К., Наджафи-Асл М., Хассани Азад М., Эстабрагния Бабаки Х.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/1783

Background. The SARS-CoV-2 pandemic has prompted researchers around the world to identify risk factors associated with disease severity and mortality. Results suggest that COVID-19 mortality might be due to a ‘cytokine storm’ involving IL-6, and that obesity can be considered a risk factor for COVID-19 prevalence, severity, and mortality. The current study aimed to evaluate the serum levels of IL-6 and adiponectin in patients and their relationship with disease progression. Materials and methods. ELISA was used to assess the levels of IL-6 and adiponectin in serum samples from a control group and from patients with COVID-19 at the time of admission to ICU or non-ICU wards. The results were analyzed using the Mann–Whitney and Spearman tests. Results. Mean serum levels of adiponectin in patients admitted to ICU (10.18±15.4 ng/ml) were significantly higher than patients admitted to non-ICU wards (3.14±3 ng/ml, p = 0.001). Mean serum IL-6 levels showed a similar pattern, however the difference was not statistically significant (p = 0.18). In addition, a significant direct correlation was observed between adiponectin expression and IL-6 (R = 0.2, p = 0.03). Conclusion. The results of this study show that serum levels of adiponectin in COVID-19 patients with severe lung involvement were significantly higher than those with less lung involvement. This finding is of high importance mainly due to the critical role of the lungs in adiponectin signaling, and as a result, adiponectin disorders may be associated with pulmonary complications in COVID-19 patients.

История вопроса. Пандемия инфекции SARS-CoV-2 побудила исследователей во всем мире выявить факторы риска, связанные с тяжестью заболевания и смертностью от него. Результаты показывают, что смертность от COVID-19 может быть связана с «цитокиновым штормом» с участием IL-6 и что ожирение можно рассматривать как фактор риска распространенности, тяжести и смертности от COVID-19. Настоящее исследование было направлено на оценку уровней IL-6 и адипонектина в сыворотке у пациентов и их связи с прогрессированием COVID-19. Материалы и методы. ИФА использовался для оценки уровней IL-6 и адипонектина в образцах сыворотки контрольной группы и пациентов с COVID-19 во время поступления в отделение интенсивной терапии или в обычные инфекционные отделения. Результаты анализировали с использованием тестов Манна–Уитни и Спирмена. Результаты. Средние уровни адипонектина в сыворотке у пациентов, поступивших в отделение интенсивной терапии (10.18±15.4 нг/мл), были значительно выше, чем у пациентов, поступивших в обычные инфекционные отделения (3.14±3 нг/мл, p = 0.001). Средние уровни IL-6 в сыворотке были сопоставимы и не имели статистически достоверных различий (p = 0.18). Кроме того, отмечена достоверная прямая корреляция между уровнем в сыворотке адипонектина и IL-6 (R = 0.2, p = 0.03). Выводы. Результаты настоящего исследования показали, что уровни адипонектина в сыворотке у пациентов с COVID-19 с тяжелым поражением легких были значительно выше, чем у пациентов с меньшей степенью поражения легких. Полученные данные имеют большое значение главным образом из-за критической роли легких в передаче сигналов от адипонектина, и, как следствие, нарушения в системе адипонектина могут быть связаны с легочными осложнениями у пациентов с COVID-19.

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