Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI1767110.15789/2220-7619-SRA-17671ORIGINAL ARTICLESОРИГИНАЛЬНЫЕ СТАТЬИResearch ArticleSeroprevalence, risk associations, and testing cost of screening for HCV, HBV, and HIV infections among a group of pre-operative Egyptian patientsСерораспространенность, ассоциации риска и стоимость скрининга на инфекции ВГС, ВГВ и ВИЧ у предоперационных пациентов в ЕгиптеHannaHany William Z.ХаннаХани Уильям З.
Egypt

MD of Clinical and Chemical Pathology, Lecturer of Clinical and Chemical Pathology, Kasr Al Ainy, Faculty of Medicine

врач клинической и химической патологии, преподаватель клинической и химической патологии, Каср Аль Айни — медицинский факультет

Hanywilliam@kasralainy.edu.egShahinR.M.H.ШахинР.М.Х. Мохамад Хосни
Egypt

MD and Professor of Clinical and Chemical Pathology, Kasr Al Ainy, Faculty of Medicine

врач, профессор клинической и химической патологии, Каср Аль Айни — медицинский факультет

Hanywilliam@kasralainy.edu.egSamyL.A.СамиЛ.А.
Egypt

MD and Lecturer of Clinical and Chemical Pathology, Kasr Al Ainy, Faculty of Medicine

врач, преподаватель клинической и химической патологии, Каср Аль Айни — медицинский факультет

Hanywilliam@kasralainy.edu.egCairo UniversityКаирский университет16092024300420251511251332605202402092024Copyright ©; 2025, Hanna H.W., Shahin R., Samy L.Copyright ©; 2025, Ханна Х.У., Шахин Р.М., Сами Л.2025Hanna H.W., Shahin R., Samy L.Ханна Х.У., Шахин Р.М., Сами Л.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/17671

Background. Routine pre-operative testing for Human Immunodeficiency Virus (HIV) and other blood-borne viruses, Hepatitis B Virus, Hepatitis C Virus (HBV, HCV) has been stated as a strategy to reduce the risk of healthcare workers’ infection by preventing and reducing their infection. However, the argument that screening is essential or not is strong. This study aims to determine the incidence of HBV, HCV, and HIV infections identified during pre-operative screening in a cohort of Egyptian individuals, along with the associated risk factors and the subsequent testing costs. Materials and methods. This study comprised 138 patients, with 92 (66.7%) males and 46 (33.3%) females. All patients scheduled for surgical procedures underwent testing for HCV Ab, HBsAg, and HIV Ag/Ab by chemiluminescent microparticle immunoassay conducted with the “ARCHITECT i2000SR Immunoassay” (Abbot Japan CO., Ltd, Tokyo, Japan). Among the participants, 23 out of 138 (16.7%) tested positive for HCV, while 5 out of 138 (3.3%) showed equivocal results for HCV, and 110 out of 138 (79.7%) tested negative for HCV. Additionally, 2 out of 138 (1.4%) were positive for HBsAg, while 136 out of 138 (98.6%) tested negative for HBsAg. Furthermore, 1 out of 138 (0.7%) was found to be HIV-positive, while 137 out of 138 (99.3%) tested negative for HIV. Results. The prevalence of each infection detected through pre-operative testing of HCV, HBV and HIV and a questionnaire was compared. Furthermore, we calculated the screening cost per confirmed infection by assessing the incidence of infections linked to different risk factors, ages, genders, and levels of HBV vaccination. Conclusions Age markedly impacted HCV and HBV rates. There was no link between viral infections and gender. The expenses associated with each affirmative result were 1763 LE for HCV, 5520 LE for HBV, and 22 080 LE for HIV. While self-assessment through questionnaires can be partially efficacious, it lacks sufficient screening accuracy.

Плановое предоперационное тестирование на вирус иммунодефицита человека (ВИЧ) и другие вирусы, передающиеся гематогенно, такие как вирус гепатита В, вирус гепатита С (ВГВ, ВГС), было предложено как стратегия снижения риска инфицирования работников здравоохранения путем профилактики и снижения их инфицирования. Однако существенным остается вопрос о необходимости проведения подобного скрининга. Настоящее исследование направлено на определение заболеваемости инфекциями ВГВ, ВГС и ВИЧ, выявленными во время предоперационного скрининга в группе пациентов в Египте, а также связанных с ними факторов риска и последующих затрат на тестирование. Материалы и методы. В исследование включены 138 пациентов, из которых 92 (66,7%) мужчины и 46 (33,3%) женщины. Все пациенты, которым были назначены хирургические манипуляции, прошли тестирование на антитела к вирусу гепатита С, HBsAg и антитела к ВИЧ Ag/Ab с помощью хемилюминесцентного иммуноанализа на микрочастицах, на приборе «ARCHITECT i2000SR» (Abbot Japan CO., Ltd, Токио, Япония). Среди участников 23 из 138 (16,7%) дали положительный результат на вирус гепатита С, в то время как 5 из 138 (3,3%) показали сомнительные результаты на вирус гепатита С, а 110 из 138 (79,7%) дали отрицательный результат на вирус гепатита С. Кроме того, 2 из 138 (1,4%) дали положительный результат на HBsAg, в то время как 136 из 138 (98,6%) дали отрицательный результат на HBsAg. Кроме того, 1 из 138 (0,7%) оказался ВИЧ-положительным, в то время как 137 из 138 (99,3%) дали отрицательный результат на ВИЧ. Результаты. Проведено сравнение распространенности каждой инфекции, выявленной с помощью предоперационного тестирования на ВГС, ВГВ и ВИЧ и анкетирования. Кроме того, были рассчитаны стоимость скрининга на подтвержденную инфекцию, оценив частоту инфекций, связанных с различными факторами риска, возрастом, полом и охватом вакцинации против ВГВ. Выводы. Возраст заметно влиял на показатели распространенности ВГС и ВГВ инфекции. Связи между вирусными инфекциями и полом не установлено. Расходы, связанные с каждым положительным результатом, составили 1763, 5520 и 22 080 египетских фунтов для ВГС, ВГВ и ВИЧ соответственно. Хотя самооценка при анкетировании может быть частично эффективной, она не обеспечивает достаточной точности скрининга.

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