Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI13810.15789/2220-7619-2013-4-301-310REVIEWSОБЗОРЫAUTOREACTIVE ANTIBODIES IN A HEALTHY HUMAN AND IN PATIENTS WITH VIRAL INFECTIONSАУТОРЕАКТИВНЫЕ АНТИТЕЛА В НОРМЕ И ПРИ ВИРУСНЫХ ИНФЕКЦИЯХKrivitskayaV. Z.КривицкаяВ. З.
Russian Federation

PhD, MD (Biology), Leading Researcher, Laboratory of Biotechnology

197376, Russian Federation, St. Petersburg, Professor Popov str., 15/17

д.б.н., ведущий научный сотрудник лаборатории биотехнологии

197376, Россия, Санкт-Петербург, ул. Профессора Попова, 15/17

vera.kriv@influenza.spb.ruResearch Institute of Influenza, Ministry of Health of the Russian Federation, St. PetersburgФГБУ НИИ гриппа МЗ РФ, Санкт-Петербург08072013343013100807201408072014Copyright ©; 2014, Krivitskaya V.Z.Copyright ©; 2014, Кривицкая В.З.2014Krivitskaya V.Z.Кривицкая В.З.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/138

Abstract. This brief review presents the data obtained during the last two decades which allow to create a new view on autoimmunity. Regulatory and protective characteristics of autoreactive natural antibodies and their role in development of effective adaptive antiviral immune response are discussed. The article considers the problem of possible autoimmune complications due to some viral infections and antiviral vaccination.

Резюме. В кратком обзоре литературы представлены данные последних двух десятилетий, позволившие сформировать новый взгляд на роль аутоиммунных процессов в жизнедеятельности организма человека. Рассмотрен вопрос о регуляторных и протективных свойствах аутореактивных нормальных антител, а также их роли в формировании эффективного адаптивного противовирусного иммунного ответа. Обсуждается проблема возможных аутоиммунных осложнений некоторых вирусных заболеваний и противовирусной вакцинации.

autoreactive antibodiesnatural antibodiespolyspecificityinnate immunityadaptive immune responseviral infectionsantiviral vaccinationаутореактивные антителанормальные антителаполиспецифичность, врожденный иммунитетадаптивный иммунный ответвирусные инфекциипротивовирусная вакцинация1. Кривицкая В.З., Сверлова М.В., Суховецкая В.Ф., Львов Н.И., Васильева И.A., Соминина А.А. Выявление аутореактивных антител класса М у пациентов с респираторными вирусными инфекциями // Медицинская иммунология. — 2008. — Т. 10, № 2–3. — С. 229–238. Krivitskaya V.Z., Sverlova M.V., Sukhovetskaya V.F., L`vov N.I., Vasil`eva I.A., Sominina A.A. Vyyavlenie autoreaktivnykh antitel klassa M u patsientov s respiratornymi virusnymi infektsiyami [Detection of autoreactive immunoglobulin M in patients affected by respiratory viral infections]. Meditsinskaya immunologiya — Medical Immunology, 2008, vol. 10, no. 2–3, pp. 229–238.2. Кривицкая В.З. 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