Russian Journal of Infection and ImmunityRussian Journal of Infection and ImmunityИнфекция и иммунитет2220-76192313-7398SPb RAACI10510.15789/2220-7619-2012-4-687-698REVIEWSОБЗОРЫTHE ROLE OF CYTOKINE GENES POLYMORPHISM IN HEPATITIS C VIRUS INFECTIONРОЛЬ ПОЛИМОРФИЗМА ГЕНОВ ЦИТОКИНОВ ПРИ ВИРУСНОМ ГЕПАТИТЕ СArsentievaN. A.АрсентьеваН. А.
Russian Federation

научный сотрудник лаборатории молекулярной иммунологии и сероэпидемиологии

197101, Санкт-Петербург, ул. Мира, 14

arsentieva_n.a@bk.ruSemenovA. V.СеменовА. В.
Russian Federation
arsentieva_n.a@bk.ruTotolianAreg A.ТотолянАрег А.
Russian Federation
arsentieva_n.a@bk.ruФБУН НИИ эпидемиологии и микробиологии имени Пастера, Санкт-Петербург04072012246876980407201404072014Copyright ©; 2014, Arsentieva N.A., Semenov A.V., Totolian A.A.Copyright ©; 2014, Арсентьева Н.А., Семенов А.В., Тотолян А.А.2014Arsentieva N.A., Semenov A.V., Totolian A.A.Арсентьева Н.А., Семенов А.В., Тотолян А.А.https://creativecommons.org/licenses/by/4.0https://iimmun.ru/iimm/article/view/105

Abstract. The outcome of hepatitis C virus (HCV) infection depends on the immune response caused by the host genetic factors. Cytokines are key mediators of inflammation and development of specific immunity, which is responsible for the elimination of HCV. It has been found that the polymorphisms in several cytokine genes play role in human susceptibility to HCV infection, determine its differences in response to HCV and treatment-induced HCV clearance. This review summarizes the results of studies on the single-nucleotide polymorphisms of cytokine genes that complete our knowledge of the pathogenesis of HCV infection.

Резюме. Исходы вирусного гепатита С зависят от иммунного ответа, обусловленного генетическим свое образием организма-хозяина. Цитокины являются ключевыми медиаторами воспалительного процесса и формирования специфического иммунитета, ответственного за естественную элиминацию вируса гепатита С. Установлено, что аллельные варианты генов цитокинов играют роль в предрасположенности человека к инфицированию вирусом гепатита С, определяют особенности его течения и тип ответа на противовирусную терапию. В настоящем обзоре обобщены результаты исследований однонуклеотидных полиморфизмов генов цитокинов, дополняющие наши знания о патогенезе вирусного гепатита С.

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